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10.3390/v13010134 http://scihub22266oqcxt.onion/10.3390/v13010134 33477902!7833398!33477902     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Viruses 2021 ; 13 (1): ä Nephropedia Template TP {{tp|p=33477902|t=2021. Structural Analysis of Neutralizing Epitopes of the SARS-CoV-2 Spike to Guide Therapy and Vaccine Design Strategies |pdf=|usr=}}{{33477902}} gab.com Text Structural Analysis of Neutralizing Epitopes of the SARS-CoV-2 Spike to Guide Therapy and Vaccine Design Strategies JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=33477902 #FOAvip Coronavirus research has gained tremendous attention because of the COVID-19 pandemic, caused by the novel severe acute respiratory syndrome coronavirus (nCoV or SARS-CoV-2). In this review, we highlight recent studies that provide atomic-resolution structural details important for the development of monoclonal antibodies (mAbs) that can be used therapeutically and prophylactically and for vaccines against SARS-CoV-2. Structural studies with SARS-CoV-2 neutralizing mAbs have revealed a diverse set of binding modes on the spike's receptor-binding domain and N-terminal domain and highlight alternative targets on the spike. We consider this structural work together with mAb effects in vivo to suggest correlations between structure and clinical applications. We also place mAbs against severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronaviruses in the context of the SARS-CoV-2 spike to suggest features that may be desirable to design mAbs or vaccines capable of conferring broad protection. Twit Text FOAVip Structural Analysis of Neutralizing Epitopes of the SARS-CoV-2 Spike to Guide Therapy and Vaccine Design Strategies ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=33477902 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33477902 #FOAvip English Wikipedia <ref>{{Cite pmid|33477902}}</ref> Structural Analysis of Neutralizing Epitopes of the SARS-CoV-2 Spike to Guide Therapy and Vaccine Design Strategies #MMPMID33477902 Finkelstein MT; Mermelstein AG; Parker Miller E; Seth PC; Stancofski ED; Fera D Viruses 2021[Jan]; 13 (1): ä PMID33477902show ga Coronavirus research has gained tremendous attention because of the COVID-19 pandemic, caused by the novel severe acute respiratory syndrome coronavirus (nCoV or SARS-CoV-2). In this review, we highlight recent studies that provide atomic-resolution structural details important for the development of monoclonal antibodies (mAbs) that can be used therapeutically and prophylactically and for vaccines against SARS-CoV-2. Structural studies with SARS-CoV-2 neutralizing mAbs have revealed a diverse set of binding modes on the spike's receptor-binding domain and N-terminal domain and highlight alternative targets on the spike. We consider this structural work together with mAb effects in vivo to suggest correlations between structure and clinical applications. We also place mAbs against severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronaviruses in the context of the SARS-CoV-2 spike to suggest features that may be desirable to design mAbs or vaccines capable of conferring broad protection. |Antibodies, Monoclonal/immunology/*therapeutic use[MESH] |Antibodies, Neutralizing/immunology/*therapeutic use[MESH] |Antibodies, Viral/immunology/*therapeutic use[MESH] |COVID-19 Serotherapy[MESH] |COVID-19/*therapy[MESH] |Epitope Mapping[MESH] |Epitopes/immunology[MESH] |Humans[MESH] |Immunization, Passive/methods[MESH] |Middle East Respiratory Syndrome Coronavirus/immunology[MESH] |SARS-CoV-2/genetics/*immunology[MESH] |Severe Acute Respiratory Syndrome/therapy[MESH] |Severe acute respiratory syndrome-related coronavirus/immunology[MESH] |Spike Glycoprotein, Coronavirus/genetics/*immunology[MESH] |Viral Vaccines/immunology[MESH]Structural Analysis of Neutralizing Epitopes of the SARS-CoV-2 Spike t(epmc).pdf DeepDyve Pubget Overpricing