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10.1002/JLB.5A0420-281R http://scihub22266oqcxt.onion/10.1002/JLB.5A0420-281R 33477200!8292449!33477200     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33477200&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       J+Leukoc+Biol 2021 ; 110 (5): 939-950 Nephropedia Template TP {{tp|p=33477200|t=2021. Myeloid-derived suppressor cells and their association with vaccine immunogenicity in South African infants |pdf=|usr=}}{{33477200}} gab.com Text Myeloid-derived suppressor cells and their association with vaccine immunogenicity in South African infants JO: J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=33477200 #FOAvip The role of Myeloid-Derived Suppressor Cells (MDSC) in infant immune ontogeny is unknown. Here, we evaluated MDSC frequency and relationship with infant vaccine responses throughout the first year of life in a prospective cohort study. Ninety-one South African infant-mother pairs were enrolled at delivery, and blood samples were collected at 0, 6, 10, and 14 weeks, 6 months, 9 months, and 1 year. MDSC frequencies were quantified, and immune responses to the childhood vaccines Bacillus Calmette-Guerin (BCG), hepatitis B (HepB), and combination diphtheria, tetanus, and pertussis (dTaP) were measured by Ag-specific CD4(+) T cell proliferation and interferon gamma (IFN-gamma) production. Vaccine-specific Ab responses to HepB, dTaP, and Haemophilus influenzae type b (Hib) were quantified via Enzyme-Linked Immunosorbent assay (ELISA). MDSC frequency in mother-infant pairs was strongly correlated; the frequency of MDSC decreased in both mothers and infants during the months after delivery/birth; and by 1 year, infant MDSC frequencies rebounded to birth levels. Higher MDSC frequency at vaccination was associated with a lack of subsequent IFN-gamma release in response to vaccine Ags, with the exception of BCG. With the exception of a weak, positive correlation between MDSC frequency at 6 weeks (time of initial vaccination) and peak Hepatitis B surface antigen Ab titer, Polymorphonuclear Myeloid-Derived Suppressor Cells (PMN-MDSC) was not correlated with T cell proliferation or Ab responses in this study. The potential for MDSC-mediated suppression of vaccine Ag-specific IFN-gamma responses should be explored further, and considered when evaluating candidate infant vaccines. Twit Text FOAVip Myeloid-derived suppressor cells and their association with vaccine immunogenicity in South African infants ????J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=33477200 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33477200 #FOAvip English Wikipedia <ref>{{Cite pmid|33477200}}</ref> Myeloid-derived suppressor cells and their association with vaccine immunogenicity in South African infants #MMPMID33477200 Kidzeru E; Gasper MA; Shao D; Edlefsen PT; Lejarcegui N; Havyarimana E; Urdahl K; Gantt S; Horton H; Jaspan H; Gervassi A J Leukoc Biol 2021[Nov]; 110 (5): 939-950 PMID33477200show ga The role of Myeloid-Derived Suppressor Cells (MDSC) in infant immune ontogeny is unknown. Here, we evaluated MDSC frequency and relationship with infant vaccine responses throughout the first year of life in a prospective cohort study. Ninety-one South African infant-mother pairs were enrolled at delivery, and blood samples were collected at 0, 6, 10, and 14 weeks, 6 months, 9 months, and 1 year. MDSC frequencies were quantified, and immune responses to the childhood vaccines Bacillus Calmette-Guerin (BCG), hepatitis B (HepB), and combination diphtheria, tetanus, and pertussis (dTaP) were measured by Ag-specific CD4(+) T cell proliferation and interferon gamma (IFN-gamma) production. Vaccine-specific Ab responses to HepB, dTaP, and Haemophilus influenzae type b (Hib) were quantified via Enzyme-Linked Immunosorbent assay (ELISA). MDSC frequency in mother-infant pairs was strongly correlated; the frequency of MDSC decreased in both mothers and infants during the months after delivery/birth; and by 1 year, infant MDSC frequencies rebounded to birth levels. Higher MDSC frequency at vaccination was associated with a lack of subsequent IFN-gamma release in response to vaccine Ags, with the exception of BCG. With the exception of a weak, positive correlation between MDSC frequency at 6 weeks (time of initial vaccination) and peak Hepatitis B surface antigen Ab titer, Polymorphonuclear Myeloid-Derived Suppressor Cells (PMN-MDSC) was not correlated with T cell proliferation or Ab responses in this study. The potential for MDSC-mediated suppression of vaccine Ag-specific IFN-gamma responses should be explored further, and considered when evaluating candidate infant vaccines. |Antibodies, Bacterial/blood/immunology[MESH] |BCG Vaccine/immunology[MESH] |Cohort Studies[MESH] |Diphtheria-Tetanus-Pertussis Vaccine/immunology[MESH] |Female[MESH] |Hepatitis B Vaccines/immunology[MESH] |Humans[MESH] |Immunogenicity, Vaccine/*immunology[MESH] |Infant[MESH] |Infant, Newborn[MESH] |Male[MESH] |Myeloid-Derived Suppressor Cells/*immunology[MESH] |Prospective Studies[MESH]Myeloid-derived suppressor cells and their association with vaccine i(epmc).pdf DeepDyve Pubget Overpricing