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10.1016/j.nut.2020.111123

http://scihub22266oqcxt.onion/10.1016/j.nut.2020.111123
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suck abstract from ncbi


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pmid33476998      Nutrition 2021 ; 84 (ä): 111123
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  • Predictive value of the prognostic nutritional index for the severity of coronavirus disease 2019 #MMPMID33476998
  • Hu X; Deng H; Wang Y; Chen L; Gu X; Wang X
  • Nutrition 2021[Apr]; 84 (ä): 111123 PMID33476998show ga
  • OBJECTIVES: Malnutrition plays a critical role in the onset and progress of the coronavirus disease 2019 (COVID-19). The aim of the present study was to explore the association of the prognostic nutritional index (PNI) score with the severity of COVID-19 and its predictive value of the severe form of COVID-19. METHODS: Clinical data were collected from 122 patients infected with COVID-19 and hospitalized at the Sixth People's Hospital of Wenzhou, China, a specialized infectious hospital affiliated with the Wenzhou Central Hospital. PNI score was calculated as serum albumin (g/L) + 5 x total lymphocyte count (/nL). RESULTS: The study population consisted of 105 patients (86.1%) with a common form and 17 patients (13.9%) with a severe form of COVID-19. PNI score significantly decreased from patients with common to severe forms of COVID-19 (P = .029) regardless of sex, age range, and body mass index (BMI). After adjustment for sex, age, indexes of liver and renal function, C-reactive protein, and current smoking status, PNI scores remained independently and inversely associated with the severity of COVID-19 (odd ratio: 0.797; P = .030). A receiver operating characteristic analysis showed that PNI scores had a similar accuracy to predict severe forms of COVID-19 compared with its combination with sex, age, and BMI (P = .402). PNI < 49 was defined as the cutoff value to predict the severe form of COVID-19. CONCLUSIONS: Poorer nutritional status predisposed patients infected with COVID-19 to its severe form. Independently associated with the severity of COVID-19, PNI score could serve as a simple, fast, and effective predictor among patients with different sex, age, and BMI.
  • |*Nutrition Assessment[MESH]
  • |*Nutritional Status[MESH]
  • |*Severity of Illness Index[MESH]
  • |Adult[MESH]
  • |C-Reactive Protein/analysis[MESH]
  • |COVID-19/blood/*physiopathology/virology[MESH]
  • |China[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Lymphocyte Count[MESH]
  • |Male[MESH]
  • |Malnutrition/*virology[MESH]
  • |Middle Aged[MESH]
  • |Predictive Value of Tests[MESH]
  • |Prognosis[MESH]
  • |ROC Curve[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]


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