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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Am+Acad+Dermatol 2021 ; 84 (5): 1356-1363 Nephropedia Template TP
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The clinical spectrum of COVID-19-associated cutaneous manifestations: An Italian multicenter study of 200 adult patients #MMPMID33476725
Marzano AV; Genovese G; Moltrasio C; Gaspari V; Vezzoli P; Maione V; Misciali C; Sena P; Patrizi A; Offidani A; Quaglino P; Arco R; Caproni M; Rovesti M; Bordin G; Recalcati S; Potenza C; Guarneri C; Fabbrocini G; Tomasini C; Sorci M; Lombardo M; Gisondi P; Conti A; Casazza G; Peris K; Calzavara-Pinton P; Berti E
J Am Acad Dermatol 2021[May]; 84 (5): 1356-1363 PMID33476725show ga
BACKGROUND: COVID-19 is associated with a wide range of skin manifestations. OBJECTIVE: To describe the clinical characteristics of COVID-19-associated skin manifestations and explore the relationships among the 6 main cutaneous phenotypes and systemic findings. METHODS: Twenty-one Italian Dermatology Units were asked to collect the demographic, clinical, and histopathologic data of 200 patients with COVID-19-associated skin manifestations. The severity of COVID-19 was classified as asymptomatic, mild, moderate, or severe. RESULTS: A chilblain-like acral pattern was significantly associated with a younger age (P < .0001) and, after adjusting for age, significantly associated with less severe COVID-19 (P = .0009). However, the median duration of chilblain-like lesions was significantly longer than that of the other cutaneous manifestations taken together (P < .0001). Patients with moderate/severe COVID-19 were more represented than those with asymptomatic/mild COVID-19 among the patients with cutaneous manifestations other than chilblain-like lesions, but only the confluent erythematous/maculo-papular/morbilliform phenotype was significantly associated with more severe COVID-19 (P = .015), and this significance disappeared after adjustment for age. LIMITATIONS: Laboratory confirmation of COVID-19 was not possible in all cases. CONCLUSIONS: After adjustment for age, there was no clear-cut spectrum of COVID-19 severity in patients with COVID-19-related skin manifestations, although chilblain-like acral lesions were more frequent in younger patients with asymptomatic/pauci-symptomatic COVID-19.