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10.1016/j.lfs.2021.119099 http://scihub22266oqcxt.onion/10.1016/j.lfs.2021.119099 33476632!7816566!33476632     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Life+Sci 2021 ; 269 (ä): 119099 Nephropedia Template TP {{tp|p=33476632|t=2021. Protective effect of Rosuvastatin on Azithromycin induced cardiotoxicity in a rat model |pdf=|usr=}}{{33476632}} gab.com Text Protective effect of Rosuvastatin on Azithromycin induced cardiotoxicity in a rat model JO: Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=33476632 #FOAvip AIMS: Azithromycin is widely used broad spectrum antibiotic recently used in treatment protocol of COVID-19 for its antiviral and immunomodulatory effects combined with Hydroxychloroquine or alone. Rat models showed that Azithromycin produces oxidative stress, inflammation, and apoptosis of myocardial tissue. Rosuvastatin, a synthetic statin, can attenuate myocardial ischemia with antioxidant and antiapoptotic effects. This study aims to evaluate the probable protective effect of Rosuvastatin against Azithromycin induced cardiotoxicity. MAIN METHOD: Twenty adult male albino rats were divided randomly into four groups, five rats each control, Azithromycin, Rosuvastatin, and Azithromycin +Rosuvastatin groups. Azithromycin 30 mg/kg/day and Rosuvastatin 2 mg/kg/day were administrated for two weeks by an intragastric tube. Twenty-four hours after the last dose, rats were anesthetized and the following measures were carried out; Electrocardiogram, Blood samples for Biochemical analysis of lactate dehydrogenase (LDH), and creatine phosphokinase (CPK). The animals sacrificed, hearts excised, apical part processed for H&E, immunohistochemical staining, and examined by light microscope. The remaining parts of the heart were collected for assessment of Malondialdehyde (MDA) and Reduced Glutathione (GSH). KEY FINDINGS: The results revealed that Rosuvastatin significantly ameliorates ECG changes, biochemical, and Oxidative stress markers alterations of Azithromycin. Histological evaluation from Azithromycin group showed marked areas of degeneration, myofibers disorganization, inflammatory infiltrate, and hemorrhage. Immunohistochemical evaluation showed significant increase in both Caspase 3 and Tumor necrosis factor (TNF) immune stain. Rosuvastatin treated group showed restoration of the cardiac muscle fibers in H&E and Immunohistochemical results. SIGNIFICANCE: We concluded that Rosuvastatin significantly ameliorates the toxic changes of Azithromycin on the heart. Twit Text FOAVip Protective effect of Rosuvastatin on Azithromycin induced cardiotoxicity in a rat model ????Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=33476632 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33476632 #FOAvip English Wikipedia <ref>{{Cite pmid|33476632}}</ref> Protective effect of Rosuvastatin on Azithromycin induced cardiotoxicity in a rat model #MMPMID33476632 Mansour BS; Salem NA; Kader GA; Abdel-Alrahman G; Mahmoud OM Life Sci 2021[Mar]; 269 (ä): 119099 PMID33476632show ga AIMS: Azithromycin is widely used broad spectrum antibiotic recently used in treatment protocol of COVID-19 for its antiviral and immunomodulatory effects combined with Hydroxychloroquine or alone. Rat models showed that Azithromycin produces oxidative stress, inflammation, and apoptosis of myocardial tissue. Rosuvastatin, a synthetic statin, can attenuate myocardial ischemia with antioxidant and antiapoptotic effects. This study aims to evaluate the probable protective effect of Rosuvastatin against Azithromycin induced cardiotoxicity. MAIN METHOD: Twenty adult male albino rats were divided randomly into four groups, five rats each control, Azithromycin, Rosuvastatin, and Azithromycin +Rosuvastatin groups. Azithromycin 30 mg/kg/day and Rosuvastatin 2 mg/kg/day were administrated for two weeks by an intragastric tube. Twenty-four hours after the last dose, rats were anesthetized and the following measures were carried out; Electrocardiogram, Blood samples for Biochemical analysis of lactate dehydrogenase (LDH), and creatine phosphokinase (CPK). The animals sacrificed, hearts excised, apical part processed for H&E, immunohistochemical staining, and examined by light microscope. The remaining parts of the heart were collected for assessment of Malondialdehyde (MDA) and Reduced Glutathione (GSH). KEY FINDINGS: The results revealed that Rosuvastatin significantly ameliorates ECG changes, biochemical, and Oxidative stress markers alterations of Azithromycin. Histological evaluation from Azithromycin group showed marked areas of degeneration, myofibers disorganization, inflammatory infiltrate, and hemorrhage. Immunohistochemical evaluation showed significant increase in both Caspase 3 and Tumor necrosis factor (TNF) immune stain. Rosuvastatin treated group showed restoration of the cardiac muscle fibers in H&E and Immunohistochemical results. SIGNIFICANCE: We concluded that Rosuvastatin significantly ameliorates the toxic changes of Azithromycin on the heart. |Animals[MESH] |Anti-Bacterial Agents/administration & dosage/*adverse effects[MESH] |Antioxidants/administration & dosage/pharmacology[MESH] |Apoptosis/drug effects[MESH] |Azithromycin/administration & dosage/*adverse effects[MESH] |COVID-19 Drug Treatment[MESH] |Cardiotoxicity/etiology/*prevention & control[MESH] |Disease Models, Animal[MESH] |Glutathione/metabolism[MESH] |Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology[MESH] |Inflammation/chemically induced/prevention & control[MESH] |Male[MESH] |Malondialdehyde/metabolism[MESH] |Oxidative Stress/drug effects[MESH] |Rats[MESH] |Rats, Sprague-Dawley[MESH]Protective effect of Rosuvastatin on Azithromycin induced cardiotoxici(epmc).pdf DeepDyve Pubget Overpricing