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10.1093/infdis/jiab035

http://scihub22266oqcxt.onion/10.1093/infdis/jiab035
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suck abstract from ncbi


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pmid33476387      J+Infect+Dis 2021 ; 223 (8): 1339-1344
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  • Immune Profiling to Determine Early Disease Trajectories Associated With Coronavirus Disease 2019 Mortality Rate: A Substudy from the ACTT-1 Trial #MMPMID33476387
  • Thiede JM; Gress AR; Libby SD; Ronayne CE; Matchett WE; Noren B; Billings JL; Menachery VD; Langlois RA; Kline S; Bold TD
  • J Infect Dis 2021[Apr]; 223 (8): 1339-1344 PMID33476387show ga
  • Coronavirus disease 2019 (COVID-19) outcomes are linked to host immune responses and may be affected by antiviral therapy. We investigated antibody and cytokine responses in ACTT-1 study participants enrolled at our center. We studied serum specimens from 19 hospitalized adults with COVID-19 randomized to treatment with remdesivir or placebo. We assessed severe acute respiratory syndrome coronavirus 2 antibody responses and identified cytokine signatures, using hierarchical clustering. We identified no clear immunologic trends attributable to remdesivir treatment. Seven participants were initially seronegative at study enrollment, and all 4 deaths occurred in this group with more recent symptom onset. We identified 3 dominant cytokine signatures, demonstrating different disease trajectories.
  • |Adenosine Monophosphate/analogs & derivatives/immunology/therapeutic use[MESH]
  • |Adult[MESH]
  • |Alanine/analogs & derivatives/immunology/therapeutic use[MESH]
  • |Antibodies, Viral/immunology[MESH]
  • |Antiviral Agents/immunology/therapeutic use[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |COVID-19/*immunology/*mortality/virology[MESH]
  • |Cytokines/immunology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunity/drug effects/*immunology[MESH]
  • |Male[MESH]


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