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10.1172/jci.insight.146267 http://scihub22266oqcxt.onion/10.1172/jci.insight.146267 33476301!7934937!33476301     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       JCI+Insight 2021 ; 6 (4): ä Nephropedia Template TP {{tp|p=33476301|t=2021. Effective virus-neutralizing activities in antisera from the first wave of survivors of severe COVID-19 |pdf=|usr=}}{{33476301}} gab.com Text Effective virus-neutralizing activities in antisera from the first wave of survivors of severe COVID-19 JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=33476301 #FOAvip The coronavirus disease 19 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become the worst public health crisis in a century. However, knowledge about the dynamics of antibody responses in patients with COVID-19 is still poorly understood. In this study, we performed a serological study with serum specimens collected at the acute and the convalescent phases from 104 patients with severe COVID-19 who were part of the first wave of COVID-19 cases in Wuhan, China. Our findings revealed that neutralizing antibodies to SARS-CoV-2 are persistent for at least 6 months in patients with severe COVID-19, despite that IgG levels against the receptor binding domain (RBD) and nucleocapsid protein (N) IgG declined from the acute to the convalescent phase. Moreover, we demonstrate that the level of RBD-IgG is capable of correlating with SARS-CoV-2-neutralizing activities in COVID-19 serum. In summary, our findings identify the magnitude, functionality, and longevity of antibody responses in patients with COVID-19, which sheds light on the humoral immune response to COVID-19 and would be beneficial for developing vaccines. Twit Text FOAVip Effective virus-neutralizing activities in antisera from the first wave of survivors of severe COVID-19 ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=33476301 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33476301 #FOAvip English Wikipedia <ref>{{Cite pmid|33476301}}</ref> Effective virus-neutralizing activities in antisera from the first wave of survivors of severe COVID-19 #MMPMID33476301 Han Y; Liu P; Qiu Y; Zhou J; Liu Y; Hu X; Yang Q; Huang R; Wen X; Song H; Yu P; Yang M; Zhang J; Liu WJ; Peng K; Wu G; Zhang D; Zhou X; Wu Y JCI Insight 2021[Feb]; 6 (4): ä PMID33476301show ga The coronavirus disease 19 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become the worst public health crisis in a century. However, knowledge about the dynamics of antibody responses in patients with COVID-19 is still poorly understood. In this study, we performed a serological study with serum specimens collected at the acute and the convalescent phases from 104 patients with severe COVID-19 who were part of the first wave of COVID-19 cases in Wuhan, China. Our findings revealed that neutralizing antibodies to SARS-CoV-2 are persistent for at least 6 months in patients with severe COVID-19, despite that IgG levels against the receptor binding domain (RBD) and nucleocapsid protein (N) IgG declined from the acute to the convalescent phase. Moreover, we demonstrate that the level of RBD-IgG is capable of correlating with SARS-CoV-2-neutralizing activities in COVID-19 serum. In summary, our findings identify the magnitude, functionality, and longevity of antibody responses in patients with COVID-19, which sheds light on the humoral immune response to COVID-19 and would be beneficial for developing vaccines. |Adult[MESH] |Aged[MESH] |Antibodies, Neutralizing/blood/*immunology/isolation & purification[MESH] |Antibodies, Viral/blood/*immunology/isolation & purification[MESH] |COVID-19/blood/diagnosis/*immunology/virology[MESH] |China[MESH] |Cohort Studies[MESH] |Female[MESH] |Humans[MESH] |Immune Sera[MESH] |Immunity, Humoral[MESH] |Immunoglobulin G/blood/*immunology/isolation & purification[MESH] |Male[MESH] |Middle Aged[MESH] |SARS-CoV-2/*immunology[MESH] |Survivors[MESH]Effective virus-neutralizing activities in antisera from the first wav(epmc).pdf DeepDyve Pubget Overpricing