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10.1038/s41467-020-20789-7 http://scihub22266oqcxt.onion/10.1038/s41467-020-20789-7 33473140!7817669!33473140     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 469 Nephropedia Template TP {{tp|p=33473140|t=2021. Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape |pdf=|usr=}}{{33473140}} gab.com Text Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33473140 #FOAvip Antibody cocktails represent a promising approach to prevent SARS-CoV-2 escape. The determinants for selecting antibody combinations and the mechanism that antibody cocktails prevent viral escape remain unclear. We compared the critical residues in the receptor-binding domain (RBD) used by multiple neutralizing antibodies and cocktails and identified a combination of two antibodies CoV2-06 and CoV2-14 for preventing viral escape. The two antibodies simultaneously bind to non-overlapping epitopes and independently compete for receptor binding. SARS-CoV-2 rapidly escapes from individual antibodies by generating resistant mutations in vitro, but it doesn't escape from the cocktail due to stronger mutational constraints on RBD-ACE2 interaction and RBD protein folding requirements. We also identified a conserved neutralizing epitope shared between SARS-CoV-2 and SARS-CoV for antibody CoV2-12. Treatments with CoV2-06 and CoV2-14 individually and in combination confer protection in mice. These findings provide insights for rational selection and mechanistic understanding of antibody cocktails as candidates for treating COVID-19. Twit Text FOAVip Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33473140 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33473140 #FOAvip English Wikipedia <ref>{{Cite pmid|33473140}}</ref> Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape #MMPMID33473140 Ku Z; Xie X; Davidson E; Ye X; Su H; Menachery VD; Li Y; Yuan Z; Zhang X; Muruato AE; I Escuer AG; Tyrell B; Doolan K; Doranz BJ; Wrapp D; Bates PF; McLellan JS; Weiss SR; Zhang N; Shi PY; An Z Nat Commun 2021[Jan]; 12 (1): 469 PMID33473140show ga Antibody cocktails represent a promising approach to prevent SARS-CoV-2 escape. The determinants for selecting antibody combinations and the mechanism that antibody cocktails prevent viral escape remain unclear. We compared the critical residues in the receptor-binding domain (RBD) used by multiple neutralizing antibodies and cocktails and identified a combination of two antibodies CoV2-06 and CoV2-14 for preventing viral escape. The two antibodies simultaneously bind to non-overlapping epitopes and independently compete for receptor binding. SARS-CoV-2 rapidly escapes from individual antibodies by generating resistant mutations in vitro, but it doesn't escape from the cocktail due to stronger mutational constraints on RBD-ACE2 interaction and RBD protein folding requirements. We also identified a conserved neutralizing epitope shared between SARS-CoV-2 and SARS-CoV for antibody CoV2-12. Treatments with CoV2-06 and CoV2-14 individually and in combination confer protection in mice. These findings provide insights for rational selection and mechanistic understanding of antibody cocktails as candidates for treating COVID-19. |*COVID-19 Drug Treatment[MESH] |Angiotensin-Converting Enzyme 2/metabolism[MESH] |Animals[MESH] |Antibodies, Monoclonal/chemistry/immunology/*pharmacology[MESH] |Antibodies, Neutralizing/immunology[MESH] |Antibodies, Viral/genetics/immunology[MESH] |COVID-19/virology[MESH] |Chlorocebus aethiops[MESH] |Disease Models, Animal[MESH] |Female[MESH] |Humans[MESH] |Immunoglobulin Fragments/genetics/immunology[MESH] |Immunoglobulin G/genetics/immunology[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Models, Molecular[MESH] |Mutation[MESH] |Protein Binding[MESH] |SARS-CoV-2/*drug effects/genetics/immunology[MESH] |Spike Glycoprotein, Coronavirus/genetics/immunology[MESH]Molecular determinants and mechanism for antibody cocktail preventing (epmc).pdf DeepDyve Pubget Overpricing