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Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Biomed+Environ+Sci 2020 ; 33 (12): 893-905 Nephropedia Template TP
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Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China #MMPMID33472729
Ma Y; Zhu DS; Chen RB; Shi NN; Liu SH; Fan YP; Wu GH; Yang PY; Bai JF; Chen H; Chen LY; Feng Q; Guo TM; Hou Y; Hu GF; Hu XM; Hu YH; Huang J; Huang QH; Huang SZ; Ji L; Jin HH; Lei X; Li CY; Li MQ; Li QT; Li XY; Liu H; Liu JP; Liu Z; Ma YT; Mao Y; Mo LF; Na H; Wang JW; Song FL; Sun S; Wang DT; Wang MX; Wang XY; Wang YZ; Wang YD; Wu W; Wu LP; Xiao YH; Xie HJ; Xu HM; Xu SF; Xue RX; Yang C; Yang KJ; Yuan SL; Zhang GQ; Zhang JB; Zhang LS; Zhao SS; Zhao WY; Zheng K; Zhou YC; Zhu JT; Zhu TQ; Zhang HM; Wang YP; Wang YY
Biomed Environ Sci 2020[Dec]; 33 (12): 893-905 PMID33472729show ga
OBJECTIVE: Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear. METHODS: A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients' medical records. Multivariable logistic regression models were used to estimate the odds ratio ( OR) and 95% confidence interval (95% CI) of the associations between comorbidities (cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19. RESULTS: Overall, 158 (13.6%) patients were diagnosed with severe illness and 32 (2.7%) had unfavorable outcomes. Hypertension (2.87, 1.30-6.32), type 2 diabetes (T2DM) (3.57, 2.32-5.49), cardiovascular disease (CVD) (3.78, 1.81-7.89), fatty liver disease (7.53, 1.96-28.96), hyperlipidemia (2.15, 1.26-3.67), other lung diseases (6.00, 3.01-11.96), and electrolyte imbalance (10.40, 3.00-26.10) were independently linked to increased odds of being severely ill. T2DM (6.07, 2.89-12.75), CVD (8.47, 6.03-11.89), and electrolyte imbalance (19.44, 11.47-32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission (5.46, 3.25-9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes (6.58, 1.46-29.64) within two weeks. CONCLUSION: Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes.