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10.1186/s12879-021-05793-6

http://scihub22266oqcxt.onion/10.1186/s12879-021-05793-6
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suck abstract from ncbi


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pmid33472599      BMC+Infect+Dis 2021 ; 21 (1): 89
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  • Clinical course and challenging management of early COVID-19 infection after heart transplantation: case report of two patients #MMPMID33472599
  • Tchana-Sato V; Ancion A; Tridetti J; Sakalihasan N; Hayette MP; Detry O; Delvenne P; Amabili P; Senard M; Hougrand O; Szecel D; Lavigne JP; Minga Lowampa E; Ponte C; Maquoi I; Morimont P; Van Den Bulck M; Delbouille MH; Defraigne JO; Lancellotti P
  • BMC Infect Dis 2021[Jan]; 21 (1): 89 PMID33472599show ga
  • BACKGROUND: There are limited data on Coronavirus disease 2019 (COVID-19) in solid organ transplant patients, especially in heart transplant recipients, with only a few case reports and case series described so far. Heart transplant recipients may be at particular high risk due to their comorbidities and immunosuppressed state. CASE PRESENTATION: This report describes the clinical course and the challenging management of early COVID-19 infection in two heart transplant recipients who tested positive for the SARS-CoV-2 virus in the perioperative period of the transplant procedure. The two patients developed a severe form of the disease and ultimately died despite the initiation of an antiviral monotherapy with hydroxychloroquine coupled with the interruption of mycophenolate mofetil. CONCLUSIONS: These two cases illustrate the severity and poor prognosis of COVID-19 in the perioperative period of a heart transplant. Thorough screening of donors and recipients is mandatory, and the issue of asymptomatic carriers needs to be addressed.
  • |*SARS-CoV-2[MESH]
  • |Antimalarials/therapeutic use[MESH]
  • |Antiviral Agents/therapeutic use[MESH]
  • |COVID-19/*complications/*therapy[MESH]
  • |Comorbidity[MESH]
  • |Female[MESH]
  • |Heart Transplantation/*adverse effects[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/therapeutic use[MESH]
  • |Immunocompromised Host[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Mycophenolic Acid/administration & dosage[MESH]


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