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10.1128/AAC.01146-20 http://scihub22266oqcxt.onion/10.1128/AAC.01146-20 33468464!8097473!33468464     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33468464&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Antimicrob+Agents+Chemother 2021 ; 65 (4): ? Nephropedia Template TP {{tp|p=33468464|t=2021. Inhibition of Arenaviruses by Combinations of Orally Available Approved Drugs |pdf=|usr=}}{{33468464}} gab.com Text Inhibition of Arenaviruses by Combinations of Orally Available Approved Drugs JO: Antimicrob Agents Chemother http://www.kidney.de/pget.php?&tw=1&pmid=33468464 #FOAvip Neglected diseases caused by arenaviruses such as Lassa virus (LASV) and filoviruses like Ebola virus (EBOV) primarily afflict resource-limited countries, where antiviral drug development is often minimal. Previous studies have shown that many approved drugs developed for other clinical indications inhibit EBOV and LASV and that combinations of these drugs provide synergistic suppression of EBOV, often by blocking discrete steps in virus entry. We hypothesize that repurposing of combinations of orally administered approved drugs provides effective suppression of arenaviruses. In this report, we demonstrate that arbidol, an approved influenza antiviral previously shown to inhibit EBOV, LASV, and many other viruses, inhibits murine leukemia virus (MLV) reporter viruses pseudotyped with the fusion glycoproteins (GPs) of other arenaviruses (Junin virus [JUNV], lymphocytic choriomeningitis virus [LCMV], and Pichinde virus [PICV]). Arbidol and other approved drugs, including aripiprazole, amodiaquine, sertraline, and niclosamide, also inhibit infection of cells by infectious PICV, and arbidol, sertraline, and niclosamide inhibit infectious LASV. Combining arbidol with aripiprazole or sertraline results in the synergistic suppression of LASV and JUNV GP-bearing pseudoviruses. This proof-of-concept study shows that arenavirus infection in vitro can be synergistically inhibited by combinations of approved drugs. This approach may lead to a proactive strategy with which to prepare for and control known and new arenavirus outbreaks. Twit Text FOAVip Inhibition of Arenaviruses by Combinations of Orally Available Approved Drugs ????Antimicrob Agents Chemother http://www.kidney.de/pget.php?&tw=1&pmid=33468464 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33468464 #FOAvip English Wikipedia <ref>{{Cite pmid|33468464}}</ref> Inhibition of Arenaviruses by Combinations of Orally Available Approved Drugs #MMPMID33468464 Herring S; Oda JM; Wagoner J; Kirchmeier D; O'Connor A; Nelson EA; Huang Q; Liang Y; DeWald LE; Johansen LM; Glass PJ; Olinger GG; Ianevski A; Aittokallio T; Paine MF; Fink SL; White JM; Polyak SJ Antimicrob Agents Chemother 2021[Mar]; 65 (4): ? PMID33468464show ga Neglected diseases caused by arenaviruses such as Lassa virus (LASV) and filoviruses like Ebola virus (EBOV) primarily afflict resource-limited countries, where antiviral drug development is often minimal. Previous studies have shown that many approved drugs developed for other clinical indications inhibit EBOV and LASV and that combinations of these drugs provide synergistic suppression of EBOV, often by blocking discrete steps in virus entry. We hypothesize that repurposing of combinations of orally administered approved drugs provides effective suppression of arenaviruses. In this report, we demonstrate that arbidol, an approved influenza antiviral previously shown to inhibit EBOV, LASV, and many other viruses, inhibits murine leukemia virus (MLV) reporter viruses pseudotyped with the fusion glycoproteins (GPs) of other arenaviruses (Junin virus [JUNV], lymphocytic choriomeningitis virus [LCMV], and Pichinde virus [PICV]). Arbidol and other approved drugs, including aripiprazole, amodiaquine, sertraline, and niclosamide, also inhibit infection of cells by infectious PICV, and arbidol, sertraline, and niclosamide inhibit infectious LASV. Combining arbidol with aripiprazole or sertraline results in the synergistic suppression of LASV and JUNV GP-bearing pseudoviruses. This proof-of-concept study shows that arenavirus infection in vitro can be synergistically inhibited by combinations of approved drugs. This approach may lead to a proactive strategy with which to prepare for and control known and new arenavirus outbreaks. |Administration, Oral[MESH] |Animals[MESH] |Antiviral Agents/*therapeutic use[MESH] |Arenaviridae Infections/*drug therapy/virology[MESH] |Arenavirus/*drug effects[MESH] |Cell Line[MESH] |Chlorocebus aethiops[MESH] |Drug Synergism[MESH] |Drug Therapy, Combination/methods[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Mice[MESH] |Proof of Concept Study[MESH]Inhibition of Arenaviruses by Combinations of Orally Available Approve(epmc).pdf DeepDyve Pubget Overpricing