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10.4155/fmc-2020-0226

http://scihub22266oqcxt.onion/10.4155/fmc-2020-0226
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33467912!7818771!33467912
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suck abstract from ncbi


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pmid33467912      Future+Med+Chem 2021 ; 13 (6): 587-592
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  • The potential association between PARP14 and SARS-CoV-2 infection (COVID-19) #MMPMID33467912
  • Tauber AL; Schweiker SS; Levonis SM
  • Future Med Chem 2021[Mar]; 13 (6): 587-592 PMID33467912show ga
  • Understanding the potential association between the poly (ADP-ribose) polymerase member 14 (PARP14) and the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may aid in understanding the host immunopathological response to the virus. PARP14 has an emerging role in viral infections, and this article considers its potential mechanisms for action in either a pro- or anti-viral manner. It is evident that more experimental work is required; however, PARP14 appears vital in controlling the interferon response to the SARS-CoV-2 infection and has potential roles in balancing the proinflammatory cytokines of the cytokine storm. Furthermore, the SARS-CoV-2 macrodomain can prevent the PARP14-mediated antiviral response, suggesting a more complex relationship between PARP14 activity and SARS-CoV-2 infections.
  • |COVID-19/complications/*immunology/pathology[MESH]
  • |Cytokine Release Syndrome/complications/immunology/pathology[MESH]
  • |Humans[MESH]
  • |Immunity[MESH]
  • |Inflammation/complications/immunology/pathology[MESH]
  • |Interferons/immunology[MESH]
  • |Poly(ADP-ribose) Polymerases/*immunology[MESH]


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