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10.3390/healthcare9010078

http://scihub22266oqcxt.onion/10.3390/healthcare9010078
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33467441!7830068!33467441
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suck abstract from ncbi


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pmid33467441      Healthcare+(Basel) 2021 ; 9 (1): ä
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  • May Ibrutinib Have Activity in Respiratory Complications by SARS-CoV-2? Clinical Experience in a Patient with Chronic Lymphocytic Leukemia #MMPMID33467441
  • Molina-Cerrillo J; Marquet-Palomanes J; Alonso-Gordoa T; Lopez-Jimenez J; Grande E
  • Healthcare (Basel) 2021[Jan]; 9 (1): ä PMID33467441show ga
  • COVID-19 is affecting many countries all around the world. Unfortunately, no treatment has already been approved for the management of patients infected by SARS-CoV-2. It seems that SARS-CoV-2 can induce the activation of an exaggerated immune response against itself according to different mechanisms that are not really well known. Inflammatory interleukins, such as IL-6 among others, play a central role in this uncontrolled immune response. There is a strong rational under ibrutinib use in in the treatment of immune-based diseases, such a as GVHD or RA. Ibrutinib achieves a reduction in the production of TNFalpha, IL1, IL-6 and Monocyte chemo-attractant protein-1 (MCP-1) by neutrophils and macrophages, that are key players in keeping the inflammatory process. We present our clinical experience about ibrutinib use in ARDS secondary to SARS-CoV-2 in a patient with chronic lymphocytic leukemia (CLL).
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