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10.3390/v13010109

http://scihub22266oqcxt.onion/10.3390/v13010109
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33466921!7829931!33466921
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suck abstract from ncbi


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pmid33466921      Viruses 2021 ; 13 (1): ä
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  • Domains and Functions of Spike Protein in Sars-Cov-2 in the Context of Vaccine Design #MMPMID33466921
  • Xia X
  • Viruses 2021[Jan]; 13 (1): ä PMID33466921show ga
  • The spike protein in SARS-CoV-2 (SARS-2-S) interacts with the human ACE2 receptor to gain entry into a cell to initiate infection. Both Pfizer/BioNTech's BNT162b2 and Moderna's mRNA-1273 vaccine candidates are based on stabilized mRNA encoding prefusion SARS-2-S that can be produced after the mRNA is delivered into the human cell and translated. SARS-2-S is cleaved into S1 and S2 subunits, with S1 serving the function of receptor-binding and S2 serving the function of membrane fusion. Here, I dissect in detail the various domains of SARS-2-S and their functions discovered through a variety of different experimental and theoretical approaches to build a foundation for a comprehensive mechanistic understanding of how SARS-2-S works to achieve its function of mediating cell entry and subsequent cell-to-cell transmission. The integration of structure and function of SARS-2-S in this review should enhance our understanding of the dynamic processes involving receptor binding, multiple cleavage events, membrane fusion, viral entry, as well as the emergence of new viral variants. I highlighted the relevance of structural domains and dynamics to vaccine development, and discussed reasons for the spike protein to be frequently featured in the conspiracy theory claiming that SARS-CoV-2 is artificially created.
  • |COVID-19 Vaccines/genetics/immunology[MESH]
  • |COVID-19/prevention & control/*virology[MESH]
  • |Humans[MESH]
  • |Membrane Fusion[MESH]
  • |Mutation[MESH]
  • |Protein Binding[MESH]
  • |Protein Domains[MESH]
  • |Protein Stability[MESH]
  • |Receptors, Virus/metabolism[MESH]
  • |SARS-CoV-2/genetics/immunology/*metabolism[MESH]
  • |Spike Glycoprotein, Coronavirus/*chemistry/genetics/*metabolism[MESH]


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  • suck abstract from ncbi

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