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10.1016/j.phrs.2020.105409 http://scihub22266oqcxt.onion/10.1016/j.phrs.2020.105409 33465472!ä!33465472 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pharmacol+Res 2021 ; 167 (ä): 105409 Nephropedia Template TP {{tp|p=33465472|t=2021. Therapeutic approaches targeting renin-angiotensin system in sepsis and its complications |pdf=|usr=}}{{33465472}} gab.com Text Therapeutic approaches targeting renin-angiotensin system in sepsis and its complications JO: Pharmacol Res http://www.kidney.de/pget.php?&tw=1&pmid=33465472 #FOAvip Sepsis, caused by the inappropriate host response to infection, is characterized by excessive inflammatory response and organ dysfunction, thus becomes a critical clinical problem. Commonly, sepsis may progress to septic shock and severe complications, including acute kidney injury (AKI), acute respiratory distress syndrome (ARDS), sepsis-induced myocardial dysfunction (SIMD), liver dysfunction, cerebral dysfunction, and skeletal muscle atrophy, which predominantly contribute to high mortality. Additionally, the global pandemic of coronavirus disease 2019 (COVID-19) raised the concern of development of effectve therapeutic strategies for viral sepsis. Renin-angiotensin system (RAS) may represent as a potent therapeutic target for sepsis therapy. The emerging role of RAS in the pathogenesis of sepsis has been investigated and several preclinical and clinical trials targeting RAS for sepsis treatment revealed promising outcomes. Herein, we attempt to review the effects and mechanisms of RAS manipulation on sepsis and its complications and provide new insights into optimizing RAS interventions for sepsis treatment. Twit Text FOAVip Therapeutic approaches targeting renin-angiotensin system in sepsis and its complications ????Pharmacol Res http://www.kidney.de/pget.php?&tw=1&pmid=33465472 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33465472 #FOAvip English Wikipedia <ref>{{Cite pmid|33465472}}</ref> Therapeutic approaches targeting renin-angiotensin system in sepsis and its complications #MMPMID33465472 Ning L; Rong J; Zhang Z; Xu Y Pharmacol Res 2021[May]; 167 (ä): 105409 PMID33465472show ga Sepsis, caused by the inappropriate host response to infection, is characterized by excessive inflammatory response and organ dysfunction, thus becomes a critical clinical problem. Commonly, sepsis may progress to septic shock and severe complications, including acute kidney injury (AKI), acute respiratory distress syndrome (ARDS), sepsis-induced myocardial dysfunction (SIMD), liver dysfunction, cerebral dysfunction, and skeletal muscle atrophy, which predominantly contribute to high mortality. Additionally, the global pandemic of coronavirus disease 2019 (COVID-19) raised the concern of development of effectve therapeutic strategies for viral sepsis. Renin-angiotensin system (RAS) may represent as a potent therapeutic target for sepsis therapy. The emerging role of RAS in the pathogenesis of sepsis has been investigated and several preclinical and clinical trials targeting RAS for sepsis treatment revealed promising outcomes. Herein, we attempt to review the effects and mechanisms of RAS manipulation on sepsis and its complications and provide new insights into optimizing RAS interventions for sepsis treatment. |*COVID-19 Drug Treatment[MESH] |Angiotensin Receptor Antagonists/adverse effects/*therapeutic use[MESH] |Angiotensin-Converting Enzyme Inhibitors/adverse effects/*therapeutic use[MESH] |Animals[MESH] |Antiviral Agents/adverse effects/*therapeutic use[MESH] |COVID-19/metabolism/physiopathology/virology[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Renin-Angiotensin System/*drug effects[MESH] |SARS-CoV-2/*drug effects/pathogenicity[MESH] |Sepsis/*drug therapy/metabolism/physiopathology/virology[MESH]Therapeutic approaches targeting renin-angiotensin system in sepsis an(epmc).pdf DeepDyve Pubget Overpricing