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10.1053/j.ajkd.2021.01.003

http://scihub22266oqcxt.onion/10.1053/j.ajkd.2021.01.003
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33465417!7816961!33465417
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suck abstract from ncbi


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pmid33465417      Am+J+Kidney+Dis 2021 ; 77 (5): 748-756.e1
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  • COVID-19 Among US Dialysis Patients: Risk Factors and Outcomes From a National Dialysis Provider #MMPMID33465417
  • Hsu CM; Weiner DE; Aweh G; Miskulin DC; Manley HJ; Stewart C; Ladik V; Hosford J; Lacson EC; Johnson DS; Lacson E Jr
  • Am J Kidney Dis 2021[May]; 77 (5): 748-756.e1 PMID33465417show ga
  • RATIONALE & OBJECTIVE: During the coronavirus disease 2019 (COVID-19) pandemic, patients receiving maintenance dialysis are a highly vulnerable population due to their comorbidities and circumstances that limit physical distancing during treatment. This study sought to characterize the risk factors for and outcomes following COVID-19 in this population. STUDY DESIGN: Retrospective cohort study. SETTING & PARTICIPANTS: Maintenance dialysis patients in clinics of a midsize national dialysis provider that had at least 1 patient who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from February to June 2020. PREDICTORS: Demographics, dialysis characteristics, residence in a congregated setting, comorbid conditions, measurements of frailty, and use of selected medications. OUTCOMES: COVID-19, defined as having a positive SARS-CoV-2 test result, and all-cause mortality among those with COVID-19. ANALYTICAL APPROACH: Logistic regression analyses conducted to identify clinical characteristics associated with COVID-19 and risk factors associated with mortality among patients following COVID-19. RESULTS: 438 of 7948 (5.5%) maintenance dialysis patients developed COVID-19. Male sex, Black race, in-center dialysis (vs home dialysis), treatment at an urban clinic, residence in a congregate setting, and greater comorbidity were associated with contracting COVID-19. Odds of COVID-19 were 17-fold higher for those residing in a congregated setting (odds ratio [OR], 17.10 [95% CI, 13.51-21.54]). Of the 438 maintenance dialysis patients with COVID-19, 109 (24.9%) died. Older age, heart disease, and markers of frailty were associated with mortality. LIMITATIONS: No distinction was detected between symptomatic and asymptomatic SARS-CoV-2 positivity, with asymptomatic screening limited by testing capacity during this initial COVID-19 surge period. CONCLUSIONS: COVID-19 is common among patients receiving maintenance dialysis, particularly those residing in congregate settings. Among maintenance dialysis patients with COVID-19, mortality is high, exceeding 20%.
  • |*COVID-19/mortality/therapy[MESH]
  • |*Frailty/diagnosis/epidemiology/etiology[MESH]
  • |*Kidney Failure, Chronic/epidemiology/therapy[MESH]
  • |*Renal Dialysis/methods/statistics & numerical data[MESH]
  • |Age Factors[MESH]
  • |Aged[MESH]
  • |Comorbidity[MESH]
  • |Female[MESH]
  • |Heart Diseases/*epidemiology[MESH]
  • |Humans[MESH]
  • |Infection Control/*methods[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Mortality[MESH]
  • |Nursing Homes/statistics & numerical data[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Assessment[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2/isolation & purification[MESH]


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