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10.1084/jem.20202187 http://scihub22266oqcxt.onion/10.1084/jem.20202187 33464307!7814348!33464307     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Exp+Med 2021 ; 218 (4): ä Nephropedia Template TP {{tp|p=33464307|t=2021. Mapping and role of T cell response in SARS-CoV-2-infected mice |pdf=|usr=}}{{33464307}} gab.com Text Mapping and role of T cell response in SARS-CoV-2-infected mice JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=33464307 #FOAvip Virus-specific T cells play essential roles in protection against multiple virus infections, including SARS-CoV and MERS-CoV. While SARS-CoV-2-specific T cells have been identified in COVID-19 patients, their role in the protection of SARS-CoV-2-infected mice is not established. Here, using mice sensitized for infection with SARS-CoV-2 by transduction with an adenovirus expressing the human receptor (Ad5-hACE2), we identified SARS-CoV-2-specific T cell epitopes recognized by CD4+ and CD8+ T cells in BALB/c and C57BL/6 mice. Virus-specific T cells were polyfunctional and were able to lyse target cells in vivo. Further, type I interferon pathway was proved to be critical for generating optimal antiviral T cell responses after SARS-CoV-2 infection. T cell vaccination alone partially protected SARS-CoV-2-infected mice from severe disease. In addition, the results demonstrated cross-reactive T cell responses between SARS-CoV and SARS-CoV-2, but not MERS-CoV, in mice. Understanding the role of the T cell response will guide immunopathogenesis studies of COVID-19 and vaccine design and validation. Twit Text FOAVip Mapping and role of T cell response in SARS-CoV-2-infected mice ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=33464307 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33464307 #FOAvip English Wikipedia <ref>{{Cite pmid|33464307}}</ref> Mapping and role of T cell response in SARS-CoV-2-infected mice #MMPMID33464307 Zhuang Z; Lai X; Sun J; Chen Z; Zhang Z; Dai J; Liu D; Li Y; Li F; Wang Y; Zhu A; Wang J; Yang W; Huang J; Li X; Hu L; Wen L; Zhuo J; Zhang Y; Chen D; Li S; Huang S; Shi Y; Zheng K; Zhong N; Zhao J; Zhou D; Zhao J J Exp Med 2021[Apr]; 218 (4): ä PMID33464307show ga Virus-specific T cells play essential roles in protection against multiple virus infections, including SARS-CoV and MERS-CoV. While SARS-CoV-2-specific T cells have been identified in COVID-19 patients, their role in the protection of SARS-CoV-2-infected mice is not established. Here, using mice sensitized for infection with SARS-CoV-2 by transduction with an adenovirus expressing the human receptor (Ad5-hACE2), we identified SARS-CoV-2-specific T cell epitopes recognized by CD4+ and CD8+ T cells in BALB/c and C57BL/6 mice. Virus-specific T cells were polyfunctional and were able to lyse target cells in vivo. Further, type I interferon pathway was proved to be critical for generating optimal antiviral T cell responses after SARS-CoV-2 infection. T cell vaccination alone partially protected SARS-CoV-2-infected mice from severe disease. In addition, the results demonstrated cross-reactive T cell responses between SARS-CoV and SARS-CoV-2, but not MERS-CoV, in mice. Understanding the role of the T cell response will guide immunopathogenesis studies of COVID-19 and vaccine design and validation. |Angiotensin-Converting Enzyme 2/genetics/metabolism[MESH] |Animals[MESH] |Antibodies, Neutralizing/blood[MESH] |CD4-Positive T-Lymphocytes/virology[MESH] |CD8-Positive T-Lymphocytes/virology[MESH] |COVID-19/*immunology[MESH] |Chlorocebus aethiops[MESH] |Cross Reactions[MESH] |Epitope Mapping[MESH] |Epitopes, T-Lymphocyte/*immunology[MESH] |Host-Pathogen Interactions/*physiology[MESH] |Interferon Type I/immunology/metabolism[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Mice, Inbred C57BL[MESH] |Middle East Respiratory Syndrome Coronavirus/immunology[MESH] |SARS-CoV-2/immunology/pathogenicity[MESH] |Severe acute respiratory syndrome-related coronavirus/immunology[MESH] |T-Lymphocytes/*immunology/*virology[MESH]Mapping and role of T cell response in SARS-CoV-2-infected mice (epmc).pdf DeepDyve Pubget Overpricing