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10.1111/jne.12935 http://scihub22266oqcxt.onion/10.1111/jne.12935 33462852!7995212!33462852     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Neuroendocrinol 2021 ; 33 (2): e12935 Nephropedia Template TP {{tp|p=33462852|t=2021. ACE2 in the second act of COVID-19 syndrome: Peptide dysregulation and possible correction with oestrogen |pdf=|usr=}}{{33462852}} gab.com Text ACE2 in the second act of COVID-19 syndrome: Peptide dysregulation and possible correction with oestrogen JO: J Neuroendocrinol http://www.kidney.de/pget.php?&tw=1&pmid=33462852 #FOAvip Coronavirus disease 2019 (COVID-19) has become the most critical pandemic of the 21st Century and the most severe since the 1918 influenza pandemic. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects the host by binding to angiotensin-converting enzyme 2 (ACE2). The role of ACE2 in the pathophysiology of coronavirus disease 2019 (COVID-19) is a topic of debate, with clinical and experimental evidence indicating a multifaceted relationship between ACE2 activity and disease severity. Here, we review the mechanisms by which the peptidergic substrates and products of ACE and ACE2 contribute to physiological and pathophysiological processes and hypothesise how down-regulation of ACE2 by SARS-CoV-2 cellular entry disrupts homeostasis. A better understanding of the endocrinology of the disease, in particular the neuroendocrinology of ACE2 during COVID-19, may contribute to the timely design of new therapeutic strategies, including the regulation of ACE2 itself by steroid hormones, to ameliorate the severity of COVID-19. Twit Text FOAVip ACE2 in the second act of COVID-19 syndrome: Peptide dysregulation and possible correction with oestrogen ????J Neuroendocrinol http://www.kidney.de/pget.php?&tw=1&pmid=33462852 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33462852 #FOAvip English Wikipedia <ref>{{Cite pmid|33462852}}</ref> ACE2 in the second act of COVID-19 syndrome: Peptide dysregulation and possible correction with oestrogen #MMPMID33462852 Zhang L; Zetter MA; Guerra EC; Hernandez VS; Mahata SK; Eiden LE J Neuroendocrinol 2021[Feb]; 33 (2): e12935 PMID33462852show ga Coronavirus disease 2019 (COVID-19) has become the most critical pandemic of the 21st Century and the most severe since the 1918 influenza pandemic. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects the host by binding to angiotensin-converting enzyme 2 (ACE2). The role of ACE2 in the pathophysiology of coronavirus disease 2019 (COVID-19) is a topic of debate, with clinical and experimental evidence indicating a multifaceted relationship between ACE2 activity and disease severity. Here, we review the mechanisms by which the peptidergic substrates and products of ACE and ACE2 contribute to physiological and pathophysiological processes and hypothesise how down-regulation of ACE2 by SARS-CoV-2 cellular entry disrupts homeostasis. A better understanding of the endocrinology of the disease, in particular the neuroendocrinology of ACE2 during COVID-19, may contribute to the timely design of new therapeutic strategies, including the regulation of ACE2 itself by steroid hormones, to ameliorate the severity of COVID-19. |*COVID-19 Drug Treatment[MESH] |Angiotensin-Converting Enzyme 2/*metabolism[MESH] |COVID-19/*metabolism[MESH] |Estrogens/*therapeutic use[MESH] |Humans[MESH] |Peptides/*metabolism[MESH] |Protein Binding[MESH]ACE2 in the second act of COVID-19 syndrome: Peptide dysregulation and(epmc).pdf DeepDyve Pubget Overpricing