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10.1039/d0cc06870e http://scihub22266oqcxt.onion/10.1039/d0cc06870e 33462575!8006714!33462575     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Chem+Commun+(Camb) 2021 ; 57 (12): 1430-1433 Nephropedia Template TP {{tp|p=33462575|t=2021. Mass spectrometry reveals potential of beta-lactams as SARS-CoV-2 M(pro) inhibitors |pdf=|usr=}}{{33462575}} gab.com Text Mass spectrometry reveals potential of beta-lactams as SARS-CoV-2 M(pro) inhibitors JO: Chem Commun (Camb) http://www.kidney.de/pget.php?&tw=1&pmid=33462575 #FOAvip The main viral protease (Mpro) of SARS-CoV-2 is a nucleophilic cysteine hydrolase and a current target for anti-viral chemotherapy. We describe a high-throughput solid phase extraction coupled to mass spectrometry Mpro assay. The results reveal some beta-lactams, including penicillin esters, are active site reacting Mpro inhibitors, thus highlighting the potential of acylating agents for Mpro inhibition. Twit Text FOAVip Mass spectrometry reveals potential of beta-lactams as SARS-CoV-2 M(pro) inhibitors ????Chem Commun (Camb) http://www.kidney.de/pget.php?&tw=1&pmid=33462575 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33462575 #FOAvip English Wikipedia <ref>{{Cite pmid|33462575}}</ref> Mass spectrometry reveals potential of beta-lactams as SARS-CoV-2 M(pro) inhibitors #MMPMID33462575 Malla TR; Tumber A; John T; Brewitz L; Strain-Damerell C; Owen CD; Lukacik P; Chan HTH; Maheswaran P; Salah E; Duarte F; Yang H; Rao Z; Walsh MA; Schofield CJ Chem Commun (Camb) 2021[Feb]; 57 (12): 1430-1433 PMID33462575show ga The main viral protease (Mpro) of SARS-CoV-2 is a nucleophilic cysteine hydrolase and a current target for anti-viral chemotherapy. We describe a high-throughput solid phase extraction coupled to mass spectrometry Mpro assay. The results reveal some beta-lactams, including penicillin esters, are active site reacting Mpro inhibitors, thus highlighting the potential of acylating agents for Mpro inhibition. |Acylation[MESH] |Antiviral Agents/chemistry/*pharmacology[MESH] |COVID-19/virology[MESH] |Catalytic Domain[MESH] |Cysteine Endopeptidases/*drug effects[MESH] |High-Throughput Screening Assays[MESH] |Humans[MESH] |Mass Spectrometry/*methods[MESH] |Molecular Docking Simulation[MESH] |Molecular Dynamics Simulation[MESH] |Protease Inhibitors/chemistry/*pharmacology[MESH] |SARS-CoV-2/*drug effects/enzymology[MESH]Mass spectrometry reveals potential of beta-lactams as SARS-CoV-2 M(pr(epmc).pdf DeepDyve Pubget Overpricing