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10.1016/j.annemergmed.2020.10.008 http://scihub22266oqcxt.onion/10.1016/j.annemergmed.2020.10.008 33461884!7552969!33461884     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Ann+Emerg+Med 2021 ; 77 (4): 385-394 Nephropedia Template TP {{tp|p=33461884|t=2021. Lung Ultrasonography for the Diagnosis of SARS-CoV-2 Pneumonia in the Emergency Department |pdf=|usr=}}{{33461884}} gab.com Text Lung Ultrasonography for the Diagnosis of SARS-CoV-2 Pneumonia in the Emergency Department JO: Ann Emerg Med http://www.kidney.de/pget.php?&tw=1&pmid=33461884 #FOAvip STUDY OBJECTIVE: Accurate diagnostic testing to identify severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is critical. Although highly specific, SARS-CoV-2 reverse transcriptase-polymerase chain reaction (RT-PCR) has been shown in clinical practice to be affected by a noninsignificant proportion of false-negative results. This study seeks to explore whether the integration of lung ultrasonography with clinical evaluation is associated with increased sensitivity for the diagnosis of coronavirus disease 2019 pneumonia, and therefore may facilitate the identification of false-negative SARS-CoV-2 RT-PCR results. METHODS: This prospective cohort study enrolled consecutive adult patients with symptoms potentially related to SARS-CoV-2 infection who were admitted to the emergency department (ED) of an Italian academic hospital. Immediately after the initial assessment, a lung ultrasonographic evaluation was performed and the likelihood of SARS-CoV-2 infection, based on both clinical and lung ultrasonographic findings ("integrated" assessment), was recorded. RT-PCR SARS-CoV-2 detection was subsequently performed. RESULTS: We enrolled 228 patients; 107 (46.9%) had SARS-CoV-2 infection. Sensitivity and negative predictive value of the clinical-lung ultrasonographic integrated assessment were higher than first RT-PCR result (94.4% [95% confidence interval CI 88.2% to 97.9%] versus 80.4% [95% CI 71.6% to 87.4%] and 95% [95% CI 89.5% to 98.2%] versus 85.2% [95% CI 78.3% to 90.6%], respectively). Among the 142 patients who initially had negative RT-PCR results, 21 tested positive at a subsequent molecular test performed within 72 hours. All these false-negative cases were correctly identified by the integrated assessment. CONCLUSION: This study suggests that, in patients presenting to the ED with symptoms commonly associated with SARS-CoV-2 infection, the integration of lung ultrasonography with clinical evaluation has high sensitivity and specificity for coronavirus disease 2019 pneumonia and it may help to identify false-negative results occurring with RT-PCR. Twit Text FOAVip Lung Ultrasonography for the Diagnosis of SARS-CoV-2 Pneumonia in the Emergency Department ????Ann Emerg Med http://www.kidney.de/pget.php?&tw=1&pmid=33461884 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33461884 #FOAvip English Wikipedia <ref>{{Cite pmid|33461884}}</ref> Lung Ultrasonography for the Diagnosis of SARS-CoV-2 Pneumonia in the Emergency Department #MMPMID33461884 Pivetta E; Goffi A; Tizzani M; Locatelli SM; Porrino G; Losano I; Leone D; Calzolari G; Vesan M; Steri F; Ardito A; Capuano M; Gelardi M; Silvestri G; Dutto S; Avolio M; Cavallo R; Bartalucci A; Paglieri C; Morello F; Richiardi L; Maule MM; Lupia E Ann Emerg Med 2021[Apr]; 77 (4): 385-394 PMID33461884show ga STUDY OBJECTIVE: Accurate diagnostic testing to identify severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is critical. Although highly specific, SARS-CoV-2 reverse transcriptase-polymerase chain reaction (RT-PCR) has been shown in clinical practice to be affected by a noninsignificant proportion of false-negative results. This study seeks to explore whether the integration of lung ultrasonography with clinical evaluation is associated with increased sensitivity for the diagnosis of coronavirus disease 2019 pneumonia, and therefore may facilitate the identification of false-negative SARS-CoV-2 RT-PCR results. METHODS: This prospective cohort study enrolled consecutive adult patients with symptoms potentially related to SARS-CoV-2 infection who were admitted to the emergency department (ED) of an Italian academic hospital. Immediately after the initial assessment, a lung ultrasonographic evaluation was performed and the likelihood of SARS-CoV-2 infection, based on both clinical and lung ultrasonographic findings ("integrated" assessment), was recorded. RT-PCR SARS-CoV-2 detection was subsequently performed. RESULTS: We enrolled 228 patients; 107 (46.9%) had SARS-CoV-2 infection. Sensitivity and negative predictive value of the clinical-lung ultrasonographic integrated assessment were higher than first RT-PCR result (94.4% [95% confidence interval CI 88.2% to 97.9%] versus 80.4% [95% CI 71.6% to 87.4%] and 95% [95% CI 89.5% to 98.2%] versus 85.2% [95% CI 78.3% to 90.6%], respectively). Among the 142 patients who initially had negative RT-PCR results, 21 tested positive at a subsequent molecular test performed within 72 hours. All these false-negative cases were correctly identified by the integrated assessment. CONCLUSION: This study suggests that, in patients presenting to the ED with symptoms commonly associated with SARS-CoV-2 infection, the integration of lung ultrasonography with clinical evaluation has high sensitivity and specificity for coronavirus disease 2019 pneumonia and it may help to identify false-negative results occurring with RT-PCR. |*Emergency Service, Hospital[MESH] |Adult[MESH] |Aged[MESH] |COVID-19 Nucleic Acid Testing[MESH] |COVID-19/diagnosis/*diagnostic imaging[MESH] |False Negative Reactions[MESH] |Female[MESH] |Humans[MESH] |Italy[MESH] |Lung/*diagnostic imaging[MESH] |Male[MESH] |Middle Aged[MESH] |Prospective Studies[MESH] |SARS-CoV-2[MESH] |Sensitivity and Specificity[MESH]Lung Ultrasonography for the Diagnosis of SARS-CoV-2 Pneumonia in the (epmc).pdf DeepDyve Pubget Overpricing