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10.1016/j.bios.2020.112672 http://scihub22266oqcxt.onion/10.1016/j.bios.2020.112672 33461849!7550100!33461849     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biosens+Bioelectron 2021 ; 177 (ä): 112672 Nephropedia Template TP {{tp|p=33461849|t=2021. Enhancing the performance of paper-based electrochemical impedance spectroscopy nanobiosensors: An experimental approach |pdf=|usr=}}{{33461849}} gab.com Text Enhancing the performance of paper-based electrochemical impedance spectroscopy nanobiosensors: An experimental approach JO: Biosens Bioelectron http://www.kidney.de/pget.php?&tw=1&pmid=33461849 #FOAvip Accurate, rapid, and low-cost molecular diagnostics is essential in managing outbreaks of infectious diseases, such as the pandemic of coronavirus disease 2019 (COVID-19). Accordingly, microfluidic paper-based analytical devices (muPADs) have emerged as promising diagnostic tools. Among the extensive efforts to improve the performance and usability of diagnostic tools, biosensing mechanisms based on electrochemical impedance spectroscopy (EIS) have shown great promise because of their label-free operation and high sensitivity. However, the method to improve EIS biosensing on muPADs is less explored. Here, we present an experimental approach to enhancing the performance of paper-based EIS biosensors featuring zinc oxide nanowires (ZnO NWs) directly grown on working electrodes (WEs). Through a comparison of different EIS settings and an examination of ZnO-NW effects on EIS measurements, we show that ZnO-NW-enhanced WEs function reliably with Faradaic processes utilizing iron-based electron mediators. We calibrate paper-based EIS biosensors with different morphologies of ZnO NWs and achieve a low limit of detection (0.4?pg?ml(-1)) in detecting p24 antigen as a marker for human immunodeficiency virus (HIV). Through microscopic imaging and electrochemical characterization, we reveal that the morphological and the electrochemical surface areas of ZnO-NW-enhanced WEs indicate the sensitivities and sensing ranges of the EIS nanobiosensors. Finally, we report that the EIS nanobiosensors are capable of differentiating the concentrations (blank, 10?ng?ml(-1), 100?ng?ml(-1), and 1?mug?ml(-1)) of IgG antibody (CR3022) to SARS-CoV-2 in human serum samples, demonstrating the efficacy of these devices for COVID-19 diagnosis. This work provides a methodology for the rational design of high-performance EIS muPADs and has the potential to facilitate diagnosis in pandemics. Twit Text FOAVip Enhancing the performance of paper-based electrochemical impedance spectroscopy nanobiosensors: An experimental approach ????Biosens Bioelectron http://www.kidney.de/pget.php?&tw=1&pmid=33461849 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33461849 #FOAvip English Wikipedia <ref>{{Cite pmid|33461849}}</ref> Enhancing the performance of paper-based electrochemical impedance spectroscopy nanobiosensors: An experimental approach #MMPMID33461849 Li X; Qin Z; Fu H; Li T; Peng R; Li Z; Rini JM; Liu X Biosens Bioelectron 2021[Apr]; 177 (ä): 112672 PMID33461849show ga Accurate, rapid, and low-cost molecular diagnostics is essential in managing outbreaks of infectious diseases, such as the pandemic of coronavirus disease 2019 (COVID-19). Accordingly, microfluidic paper-based analytical devices (muPADs) have emerged as promising diagnostic tools. Among the extensive efforts to improve the performance and usability of diagnostic tools, biosensing mechanisms based on electrochemical impedance spectroscopy (EIS) have shown great promise because of their label-free operation and high sensitivity. However, the method to improve EIS biosensing on muPADs is less explored. Here, we present an experimental approach to enhancing the performance of paper-based EIS biosensors featuring zinc oxide nanowires (ZnO NWs) directly grown on working electrodes (WEs). Through a comparison of different EIS settings and an examination of ZnO-NW effects on EIS measurements, we show that ZnO-NW-enhanced WEs function reliably with Faradaic processes utilizing iron-based electron mediators. We calibrate paper-based EIS biosensors with different morphologies of ZnO NWs and achieve a low limit of detection (0.4?pg?ml(-1)) in detecting p24 antigen as a marker for human immunodeficiency virus (HIV). Through microscopic imaging and electrochemical characterization, we reveal that the morphological and the electrochemical surface areas of ZnO-NW-enhanced WEs indicate the sensitivities and sensing ranges of the EIS nanobiosensors. Finally, we report that the EIS nanobiosensors are capable of differentiating the concentrations (blank, 10?ng?ml(-1), 100?ng?ml(-1), and 1?mug?ml(-1)) of IgG antibody (CR3022) to SARS-CoV-2 in human serum samples, demonstrating the efficacy of these devices for COVID-19 diagnosis. This work provides a methodology for the rational design of high-performance EIS muPADs and has the potential to facilitate diagnosis in pandemics. |Biosensing Techniques/*instrumentation/methods[MESH] |COVID-19 Serological Testing/*instrumentation/methods[MESH] |COVID-19/blood/*diagnosis[MESH] |Dielectric Spectroscopy/*instrumentation/methods[MESH] |Equipment Design[MESH] |Humans[MESH] |Lab-On-A-Chip Devices[MESH] |Limit of Detection[MESH] |Nanowires/chemistry[MESH] |Paper[MESH] |SARS-CoV-2/*isolation & purification[MESH]Enhancing the performance of paper-based electrochemical impedance spe(epmc).pdf DeepDyve Pubget Overpricing