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10.1016/j.mehy.2021.110486

http://scihub22266oqcxt.onion/10.1016/j.mehy.2021.110486
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suck abstract from ncbi


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pmid33460992      Med+Hypotheses 2021 ; 147 (ä): 110486
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  • Scientific hypothesis and rational pharmacological for the use of sacubitril/valsartan in cardiac damage caused by COVID-19 #MMPMID33460992
  • Vitiello A; La Porta R; Ferrara F
  • Med Hypotheses 2021[Feb]; 147 (ä): 110486 PMID33460992show ga
  • On March 11, 2020 the World Health Organization (WHO) declared the state of global pandemic caused by the new SARS-CoV-2 (COVID-19). To date, no antivirals directed against SARS-CoV-2 or effective vaccines to combat the viral infection are available. Severe acute respiratory syndrome caused by SARS-CoV-2 is treated empirically with antivirals, anti-inflammatory, anticoagulants. The approval of an effective vaccine still takes time. In this state, it may be useful to find new therapeutic solutions from drugs already on the market. Recent hypotheses suggest that the use of AT-1 receptor antagonists (ARB) in combination with neprilisin inhibitors (NEPi) could indirectly provide clinical benefits to patients with SARS-CoV-2 and cardiac involvement. In this article we investigate and describe a possible innovative pharmacological approach for the treatment of the most severe stages of COVID-19 infection.
  • |*COVID-19 Drug Treatment[MESH]
  • |Aminobutyrates/*administration & dosage[MESH]
  • |Angiotensin-Converting Enzyme Inhibitors[MESH]
  • |Antiviral Agents/therapeutic use[MESH]
  • |Biphenyl Compounds[MESH]
  • |Cytokine Release Syndrome/virology[MESH]
  • |Cytokines/metabolism[MESH]
  • |Drug Combinations[MESH]
  • |Heart Failure/*drug therapy/virology[MESH]
  • |Homeostasis[MESH]
  • |Humans[MESH]
  • |Inflammation[MESH]
  • |Models, Theoretical[MESH]
  • |Natriuretic Peptide, Brain/metabolism[MESH]
  • |Neprilysin/adverse effects[MESH]
  • |Peptide Fragments/metabolism[MESH]
  • |Receptor, Angiotensin, Type 2/metabolism[MESH]
  • |Tetrazoles/*administration & dosage[MESH]
  • |Valsartan/*administration & dosage[MESH]


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