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10.1016/j.bpj.2020.12.029 http://scihub22266oqcxt.onion/10.1016/j.bpj.2020.12.029 33460600!7834719!33460600     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biophys+J 2021 ; 120 (6): 1085-1096 Nephropedia Template TP {{tp|p=33460600|t=2021. Improving SARS-CoV-2 structures: Peer review by early coordinate release |pdf=|usr=}}{{33460600}} gab.com Text Improving SARS-CoV-2 structures: Peer review by early coordinate release JO: Biophys J http://www.kidney.de/pget.php?&tw=1&pmid=33460600 #FOAvip This work builds upon the record-breaking speed and generous immediate release of new experimental three-dimensional structures of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins and complexes, which are crucial to downstream vaccine and drug development. We have surveyed those structures to catch the occasional errors that could be significant for those important uses and for which we were able to provide demonstrably higher-accuracy corrections. This process relied on new validation and correction methods such as CaBLAM and ISOLDE, which are not yet in routine use. We found such important and correctable problems in seven early SARS-CoV-2 structures. Two of the structures were soon superseded by new higher-resolution data, confirming our proposed changes. For the other five, we emailed the depositors a documented and illustrated report and encouraged them to make the model corrections themselves and use the new option at the worldwide Protein Data Bank for depositors to re-version their coordinates without changing the Protein Data Bank code. This quickly and easily makes the better-accuracy coordinates available to anyone who examines or downloads their structure, even before formal publication. The changes have involved sequence misalignments, incorrect RNA conformations near a bound inhibitor, incorrect metal ligands, and cis-trans or peptide flips that prevent good contact at interaction sites. These improvements have propagated into nearly all related structures done afterward. This process constitutes a new form of highly rigorous peer review, which is actually faster and more strict than standard publication review because it has access to coordinates and maps; journal peer review would also be strengthened by such access. Twit Text FOAVip Improving SARS-CoV-2 structures: Peer review by early coordinate release ????Biophys J http://www.kidney.de/pget.php?&tw=1&pmid=33460600 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33460600 #FOAvip English Wikipedia <ref>{{Cite pmid|33460600}}</ref> Improving SARS-CoV-2 structures: Peer review by early coordinate release #MMPMID33460600 Croll TI; Williams CJ; Chen VB; Richardson DC; Richardson JS Biophys J 2021[Mar]; 120 (6): 1085-1096 PMID33460600show ga This work builds upon the record-breaking speed and generous immediate release of new experimental three-dimensional structures of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins and complexes, which are crucial to downstream vaccine and drug development. We have surveyed those structures to catch the occasional errors that could be significant for those important uses and for which we were able to provide demonstrably higher-accuracy corrections. This process relied on new validation and correction methods such as CaBLAM and ISOLDE, which are not yet in routine use. We found such important and correctable problems in seven early SARS-CoV-2 structures. Two of the structures were soon superseded by new higher-resolution data, confirming our proposed changes. For the other five, we emailed the depositors a documented and illustrated report and encouraged them to make the model corrections themselves and use the new option at the worldwide Protein Data Bank for depositors to re-version their coordinates without changing the Protein Data Bank code. This quickly and easily makes the better-accuracy coordinates available to anyone who examines or downloads their structure, even before formal publication. The changes have involved sequence misalignments, incorrect RNA conformations near a bound inhibitor, incorrect metal ligands, and cis-trans or peptide flips that prevent good contact at interaction sites. These improvements have propagated into nearly all related structures done afterward. This process constitutes a new form of highly rigorous peer review, which is actually faster and more strict than standard publication review because it has access to coordinates and maps; journal peer review would also be strengthened by such access. |*Peer Review[MESH] |Adenosine Monophosphate/analogs & derivatives/chemistry/pharmacology[MESH] |Alanine/analogs & derivatives/chemistry/pharmacology[MESH] |Antibodies, Viral[MESH] |Catalytic Domain[MESH] |DNA-Directed RNA Polymerases/metabolism[MESH] |Humans[MESH] |Models, Molecular[MESH] |Nucleocapsid/chemistry[MESH] |Phosphoproteins/chemistry[MESH] |RNA-Binding Proteins/chemistry[MESH] |SARS-CoV-2/*chemistry/drug effects[MESH] |Spike Glycoprotein, Coronavirus/chemistry/metabolism[MESH]Improving SARS-CoV-2 structures: Peer review by early coordinate relea(epmc).pdf DeepDyve Pubget Overpricing