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A large-scale transcriptional study reveals inhibition of COVID-19 related cytokine storm by traditional Chinese medicines #MMPMID33457042
Dai Y; Qiang W; Gui Y; Tan X; Pei T; Lin K; Cai S; Sun L; Ning G; Wang J; Guo H; Sun Y; Cheng J; Xie L; Lan X; Wang D
Sci Bull (Beijing) 2021[May]; 66 (9): 884-888 PMID33457042show ga
Coronavirus disease-2019 (COVID-19) has become a major global epidemic. Facilitated by HTS(2) technology, we evaluated the effects of 578 herbs and all 338 reported anti-COVID-19 TCM formulae on cytokine storm-related signaling pathways, and identified the key targets of the relevant pathways and potential active ingredients in these herbs. This large-scale transcriptional study innovatively combines HTS(2) technology with bioinformatics methods and computer-aided drug design. For the first time, it systematically explores the molecular mechanism of TCM in regulating the COVID-19-related cytokine storm, providing an important scientific basis for elucidating the mechanism of action of TCM in treating COVID-19.