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10.11604/pamj.supp.2020.37.30.25851

http://scihub22266oqcxt.onion/10.11604/pamj.supp.2020.37.30.25851
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33456654!7796835!33456654
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suck abstract from ncbi


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pmid33456654      Pan+Afr+Med+J 2020 ; 37 (Suppl 1): 30
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  • Use of tocilizumab in a patient with severe COVID-19 in a Teaching Hospital in Ghana: a case report #MMPMID33456654
  • Hardy YO; Hutton-Mensah KA; Amenuke DAY; Amoah-Dankwah J
  • Pan Afr Med J 2020[]; 37 (Suppl 1): 30 PMID33456654show ga
  • The outbreak of coronavirus disease 2019 (COVID-19) in December 2019 has rapidly spread globally with significant negative impact on health. There is an urgent need for a drug or vaccine certified for treating and preventing COVID-19 respectively. Tocilizumab, an interleukin-6 monoclonal receptor antibody, has been used in some centers for mitigating the severe inflammatory response seen in patients with severe COVID-19 with encouraging results. To the best of our knowledge, reports detailing the outcomes of patients with severe COVID-19 undergoing treatment with tocilizumab are sparse in sub-Saharan Africa. We describe the clinical and laboratory profile, chest Computed Tomography (CT) scan findings and clinical outcome in a Ghanaian patient with severe COVID-19 pneumonia treated with tocilizumab. A 54-year-old hypertensive male presented with fever, productive cough, pleuritic chest pain and breathlessness. He tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by polymerase chain reaction analysis done on a nasopharyngeal swab sample. His respiratory symptoms worsened while on admission despite receiving standard of care. His C-reactive protein (CRP) was elevated to 80.59mg/L and chest CT scan findings were indicative of severe COVID-19 pneumonia. He was treated with a single 400mg dose of intravenous tocilizumab with a positive clinical outcome, rapid decline in CRP and improvement in chest CT findings. Our experience shows that tocilizumab shows great promise as drug therapy for COVID-19 pneumonia.
  • |*COVID-19 Drug Treatment[MESH]
  • |Antibodies, Monoclonal, Humanized/*therapeutic use[MESH]
  • |COVID-19/diagnosis[MESH]
  • |Ghana[MESH]
  • |Hospitals, Teaching[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]


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