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10.1159/000513686 http://scihub22266oqcxt.onion/10.1159/000513686 33454715!7900486!33454715     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Intervirology 2021 ; 64 (2): 55-68 Nephropedia Template TP {{tp|p=33454715|t=2021. Structures of SARS-CoV-2 RNA-Binding Proteins and Therapeutic Targets |pdf=|usr=}}{{33454715}} gab.com Text Structures of SARS-CoV-2 RNA-Binding Proteins and Therapeutic Targets JO: Intervirology http://www.kidney.de/pget.php?&tw=1&pmid=33454715 #FOAvip BACKGROUND: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) epidemic has resulted in thousands of infections and deaths worldwide. Several therapies are currently undergoing clinical trials for the treatment of SARS-CoV-2 infection. However, the development of new drugs and the repositioning of existing drugs can only be achieved after the identification of potential therapeutic targets within structures, as this strategy provides the most precise solution for developing treatments for sudden epidemic infectious diseases. SUMMARY: In the current investigation, crystal and cryo-electron microscopy structures encoded by the SARS-CoV-2 genome were systematically examined for the identification of potential drug targets. These structures include nonstructural proteins (Nsp-9; Nsp-12; and Nsp-15), nucleocapsid (N) proteins, and the main protease (Mpro). Key Message: The structural information reveals the presence of many potential alternative therapeutic targets, primarily involved in interaction between N protein and Nsp3, forming replication-transcription complexes (RTCs) which might be a potential drug target for effective control of current SARS-CoV-2 pandemic. RTCs consist of 16 nonstructural proteins (Nsp1-16) that play the most essential role in the synthesis of viral RNA. Targeting the physical linkage between the envelope and single-stranded positive RNA, a process facilitated by matrix proteins may provide a good alternative strategy. Our current study provides useful information for the development of new lead compounds against SARS-CoV-2 infections. Twit Text FOAVip Structures of SARS-CoV-2 RNA-Binding Proteins and Therapeutic Targets ????Intervirology http://www.kidney.de/pget.php?&tw=1&pmid=33454715 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33454715 #FOAvip English Wikipedia <ref>{{Cite pmid|33454715}}</ref> Structures of SARS-CoV-2 RNA-Binding Proteins and Therapeutic Targets #MMPMID33454715 Khan MT; Irfan M; Ahsan H; Ahmed A; Kaushik AC; Khan AS; Chinnasamy S; Ali A; Wei DQ Intervirology 2021[]; 64 (2): 55-68 PMID33454715show ga BACKGROUND: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) epidemic has resulted in thousands of infections and deaths worldwide. Several therapies are currently undergoing clinical trials for the treatment of SARS-CoV-2 infection. However, the development of new drugs and the repositioning of existing drugs can only be achieved after the identification of potential therapeutic targets within structures, as this strategy provides the most precise solution for developing treatments for sudden epidemic infectious diseases. SUMMARY: In the current investigation, crystal and cryo-electron microscopy structures encoded by the SARS-CoV-2 genome were systematically examined for the identification of potential drug targets. These structures include nonstructural proteins (Nsp-9; Nsp-12; and Nsp-15), nucleocapsid (N) proteins, and the main protease (Mpro). Key Message: The structural information reveals the presence of many potential alternative therapeutic targets, primarily involved in interaction between N protein and Nsp3, forming replication-transcription complexes (RTCs) which might be a potential drug target for effective control of current SARS-CoV-2 pandemic. RTCs consist of 16 nonstructural proteins (Nsp1-16) that play the most essential role in the synthesis of viral RNA. Targeting the physical linkage between the envelope and single-stranded positive RNA, a process facilitated by matrix proteins may provide a good alternative strategy. Our current study provides useful information for the development of new lead compounds against SARS-CoV-2 infections. |*COVID-19 Drug Treatment[MESH] |Antiviral Agents/chemistry/pharmacology[MESH] |COVID-19/virology[MESH] |Humans[MESH] |Models, Molecular[MESH] |Molecular Targeted Therapy[MESH] |RNA, Viral/chemistry/genetics[MESH] |RNA-Binding Proteins/*chemistry/genetics/metabolism[MESH]Structures of SARS-CoV-2 RNA-Binding Proteins and Therapeutic Targets (epmc).pdf DeepDyve Pubget Overpricing