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10.1016/j.lfs.2021.119046 http://scihub22266oqcxt.onion/10.1016/j.lfs.2021.119046 33453245!7806453!33453245     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33453245.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Life+Sci 2021 ; 269 (ä): 119046 Nephropedia Template TP {{tp|p=33453245|t=2021. The proteomic characteristics of airway mucus from critical ill COVID-19 patients |pdf=|usr=}}{{33453245}} gab.com Text The proteomic characteristics of airway mucus from critical ill COVID-19 patients JO: Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=33453245 #FOAvip BACKGROUND: The pandemic of the coronavirus disease 2019 (COVID-19) has brought a global public health crisis. However, the pathogenesis underlying COVID-19 are barely understood. METHODS: In this study, we performed proteomic analyses of airway mucus obtained by bronchoscopy from severe COVID-19 patients. In total, 2351 and 2073 proteins were identified and quantified in COVID-19 patients and healthy controls, respectively. RESULTS: Among them, 92 differentiated expressed proteins (DEPs) (46 up-regulated and 46 down-regulated) were found with a fold change >1.5 or <0.67 and a p-value <0.05, and 375 proteins were uniquely present in airway mucus from COVID-19 patients. Pathway and network enrichment analyses revealed that the 92 DEPs were mostly associated with metabolic, complement and coagulation cascades, lysosome, and cholesterol metabolism pathways, and the 375 COVID-19 only proteins were mainly enriched in amino acid degradation (Valine, Leucine and Isoleucine degradation), amino acid metabolism (beta-Alanine, Tryptophan, Cysteine and Methionine metabolism), oxidative phosphorylation, phagosome, and cholesterol metabolism pathways. CONCLUSIONS: This study aims to provide fundamental data for elucidating proteomic changes of COVID-19, which may implicate further investigation of molecular targets directing at specific therapy. Twit Text FOAVip The proteomic characteristics of airway mucus from critical ill COVID-19 patients ????Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=33453245 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33453245 #FOAvip English Wikipedia <ref>{{Cite pmid|33453245}}</ref> The proteomic characteristics of airway mucus from critical ill COVID-19 patients #MMPMID33453245 Zhang Z; Wang T; Liu F; Zhu A; Gu G; Luo J; Xu J; Zhao J; Li Y; Li Y; Liu X; Zhong N; Lu W Life Sci 2021[Mar]; 269 (ä): 119046 PMID33453245show ga BACKGROUND: The pandemic of the coronavirus disease 2019 (COVID-19) has brought a global public health crisis. However, the pathogenesis underlying COVID-19 are barely understood. METHODS: In this study, we performed proteomic analyses of airway mucus obtained by bronchoscopy from severe COVID-19 patients. In total, 2351 and 2073 proteins were identified and quantified in COVID-19 patients and healthy controls, respectively. RESULTS: Among them, 92 differentiated expressed proteins (DEPs) (46 up-regulated and 46 down-regulated) were found with a fold change >1.5 or <0.67 and a p-value <0.05, and 375 proteins were uniquely present in airway mucus from COVID-19 patients. Pathway and network enrichment analyses revealed that the 92 DEPs were mostly associated with metabolic, complement and coagulation cascades, lysosome, and cholesterol metabolism pathways, and the 375 COVID-19 only proteins were mainly enriched in amino acid degradation (Valine, Leucine and Isoleucine degradation), amino acid metabolism (beta-Alanine, Tryptophan, Cysteine and Methionine metabolism), oxidative phosphorylation, phagosome, and cholesterol metabolism pathways. CONCLUSIONS: This study aims to provide fundamental data for elucidating proteomic changes of COVID-19, which may implicate further investigation of molecular targets directing at specific therapy. |Aged[MESH] |Amino Acids/*metabolism[MESH] |Bronchoscopy[MESH] |COVID-19/*physiopathology[MESH] |Case-Control Studies[MESH] |Cholesterol/metabolism[MESH] |Critical Illness[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Mucus/*virology[MESH] |Proteins/*metabolism[MESH] |Proteomics[MESH]The proteomic characteristics of airway mucus from critical ill COVID-(epmc).pdf DeepDyve Pubget Overpricing