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10.1038/s41467-020-20699-8 http://scihub22266oqcxt.onion/10.1038/s41467-020-20699-8 33452267!7810722!33452267     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 378 Nephropedia Template TP {{tp|p=33452267|t=2021. The challenges of containing SARS-CoV-2 via test-trace-and-isolate |pdf=|usr=}}{{33452267}} gab.com Text The challenges of containing SARS-CoV-2 via test-trace-and-isolate JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33452267 #FOAvip Without a cure, vaccine, or proven long-term immunity against SARS-CoV-2, test-trace-and-isolate (TTI) strategies present a promising tool to contain its spread. For any TTI strategy, however, mitigation is challenged by pre- and asymptomatic transmission, TTI-avoiders, and undetected spreaders, which strongly contribute to "hidden" infection chains. Here, we study a semi-analytical model and identify two tipping points between controlled and uncontrolled spread: (1) the behavior-driven reproduction number [Formula: see text] of the hidden chains becomes too large to be compensated by the TTI capabilities, and (2) the number of new infections exceeds the tracing capacity. Both trigger a self-accelerating spread. We investigate how these tipping points depend on challenges like limited cooperation, missing contacts, and imperfect isolation. Our results suggest that TTI alone is insufficient to contain an otherwise unhindered spread of SARS-CoV-2, implying that complementary measures like social distancing and improved hygiene remain necessary. Twit Text FOAVip The challenges of containing SARS-CoV-2 via test-trace-and-isolate ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33452267 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33452267 #FOAvip English Wikipedia <ref>{{Cite pmid|33452267}}</ref> The challenges of containing SARS-CoV-2 via test-trace-and-isolate #MMPMID33452267 Contreras S; Dehning J; Loidolt M; Zierenberg J; Spitzner FP; Urrea-Quintero JH; Mohr SB; Wilczek M; Wibral M; Priesemann V Nat Commun 2021[Jan]; 12 (1): 378 PMID33452267show ga Without a cure, vaccine, or proven long-term immunity against SARS-CoV-2, test-trace-and-isolate (TTI) strategies present a promising tool to contain its spread. For any TTI strategy, however, mitigation is challenged by pre- and asymptomatic transmission, TTI-avoiders, and undetected spreaders, which strongly contribute to "hidden" infection chains. Here, we study a semi-analytical model and identify two tipping points between controlled and uncontrolled spread: (1) the behavior-driven reproduction number [Formula: see text] of the hidden chains becomes too large to be compensated by the TTI capabilities, and (2) the number of new infections exceeds the tracing capacity. Both trigger a self-accelerating spread. We investigate how these tipping points depend on challenges like limited cooperation, missing contacts, and imperfect isolation. Our results suggest that TTI alone is insufficient to contain an otherwise unhindered spread of SARS-CoV-2, implying that complementary measures like social distancing and improved hygiene remain necessary. |Algorithms[MESH] |COVID-19 Testing/*methods[MESH] |COVID-19/epidemiology/*prevention & control/virology[MESH] |Communicable Disease Control/methods[MESH] |Contact Tracing/*methods[MESH] |Humans[MESH] |Mass Screening/*methods[MESH] |Models, Theoretical[MESH] |Pandemics[MESH] |Reproducibility of Results[MESH]The challenges of containing SARS-CoV-2 via test-trace-and-isolate (epmc).pdf DeepDyve Pubget Overpricing