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10.1016/j.transproceed.2020.11.009

http://scihub22266oqcxt.onion/10.1016/j.transproceed.2020.11.009
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suck abstract from ncbi


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pmid33451759      Transplant+Proc 2021 ; 53 (4): 1112-1117
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  • SARS-CoV-2 Seroprevalence and Clinical Features of COVID-19 in a German Liver Transplant Recipient Cohort: A Prospective Serosurvey Study #MMPMID33451759
  • Rauber C; Tiwari-Heckler S; Pfeiffenberger J; Mehrabi A; Lund F; Gath P; Mieth M; Merle U; Rupp C
  • Transplant Proc 2021[May]; 53 (4): 1112-1117 PMID33451759show ga
  • BACKGROUND: In liver transplant (LT) recipients with severe coronavirus disease 2019 (COVID-19), fatal outcome has been reported in a substantial subset of patients. Whether LT recipients are at increased risk for severe COVID-19 compared with the general population is controversial. Here we report the results of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serosurvey in a large LT recipient cohort. METHODS: A total of 219 LT recipients were enrolled between May 5, 2020, and August 6, 2020, at the University Hospital Heidelberg. Serum blood samples were collected and tested for anti-SARS-CoV-2 IgG. SARS-CoV-2 RNA was detected in nasopharyngeal swabs using reverse transcription-polymerase chain reaction assays. RESULTS: Taking into account known risk factors of arterial hypertension, obesity, diabetes, or leukopenia, LT recipients a priori represented a high-risk cohort for severe COVID-19 with 101 of 219 (46.1%) presenting with more than 2 risk factors for severe COVID-19. Out of 219 LT recipients, 8 (3.7%) either had a positive test result for nasopharyngeal SARS-CoV-2 RNA or anti-SARS-CoV-2 serum IgG. Five of eight (62.5%) did not show any clinical signs of infection, three of eight (37.5%) had self-limited disease, and none required hospitalization for COVID-19. Two of eight (25%) had known exposure to infected health care staff as the probable source of infection. CONCLUSIONS: In summary, LT recipients showed a SARS-CoV-2 seroconversion rate similar to that of the general population with a substantial percentage of unrecognized infections.
  • |Adult[MESH]
  • |Antibodies, Viral/blood[MESH]
  • |COVID-19/*epidemiology/immunology[MESH]
  • |Female[MESH]
  • |Germany/epidemiology[MESH]
  • |Humans[MESH]
  • |Immunoglobulin G/blood/immunology[MESH]
  • |Liver Transplantation/*adverse effects[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Postoperative Complications/*epidemiology/immunology[MESH]
  • |Prospective Studies[MESH]
  • |RNA, Viral/blood[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2/*immunology[MESH]
  • |Seroconversion[MESH]


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