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10.1016/j.virol.2020.12.020 http://scihub22266oqcxt.onion/10.1016/j.virol.2020.12.020 33450669!7787511!33450669     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Virology 2021 ; 555 (ä): 35-43 Nephropedia Template TP {{tp|p=33450669|t=2021. Incomplete humoral response including neutralizing antibodies in asymptomatic to mild COVID-19 patients in Japan |pdf=|usr=}}{{33450669}} gab.com Text Incomplete humoral response including neutralizing antibodies in asymptomatic to mild COVID-19 patients in Japan JO: Virology http://www.kidney.de/pget.php?&tw=1&pmid=33450669 #FOAvip The pandemic of COVID-19 is still ongoing, and many studies on serum antibodies have been reported, however, there are few studies about asymptomatic and mild patients. In this study, we enrolled 44 COVID-19 patients with relatively mild disease and 48 pre-pandemic controls. We measured serum antibodies against extracellular domain, S1 domain, and receptor-binding domain of Spike and N protein, examined neutralization titers by authentic virus neutralization assay and newly-developed bead/cell-based Spike-ACE2 inhibition assay, and compared them with clinical features. Most of these antibodies, including neutralizing titers, were mutually correlated, and the production of antibodies were associated with low Ct values of PCR test, disease severity, symptoms especially pneumonia, lymphopenia, and serological test including CRP, LD, D-dimer, and procalcitonin. Notably, 87.5% of asymptomatic and 23.5% of mild patients did not have antibody against SARS-CoV-2. Our results revealed the inadequate acquisition of humoral immunity in patients with asymptomatic and mild COVID-19 patients. Twit Text FOAVip Incomplete humoral response including neutralizing antibodies in asymptomatic to mild COVID-19 patients in Japan ????Virology http://www.kidney.de/pget.php?&tw=1&pmid=33450669 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33450669 #FOAvip English Wikipedia <ref>{{Cite pmid|33450669}}</ref> Incomplete humoral response including neutralizing antibodies in asymptomatic to mild COVID-19 patients in Japan #MMPMID33450669 Takeshita M; Nishina N; Moriyama S; Takahashi Y; Uwamino Y; Nagata M; Aoki W; Masaki K; Ishii M; Saya H; Kondo Y; Kaneko Y; Suzuki K; Fukunaga K; Takeuchi T Virology 2021[Mar]; 555 (ä): 35-43 PMID33450669show ga The pandemic of COVID-19 is still ongoing, and many studies on serum antibodies have been reported, however, there are few studies about asymptomatic and mild patients. In this study, we enrolled 44 COVID-19 patients with relatively mild disease and 48 pre-pandemic controls. We measured serum antibodies against extracellular domain, S1 domain, and receptor-binding domain of Spike and N protein, examined neutralization titers by authentic virus neutralization assay and newly-developed bead/cell-based Spike-ACE2 inhibition assay, and compared them with clinical features. Most of these antibodies, including neutralizing titers, were mutually correlated, and the production of antibodies were associated with low Ct values of PCR test, disease severity, symptoms especially pneumonia, lymphopenia, and serological test including CRP, LD, D-dimer, and procalcitonin. Notably, 87.5% of asymptomatic and 23.5% of mild patients did not have antibody against SARS-CoV-2. Our results revealed the inadequate acquisition of humoral immunity in patients with asymptomatic and mild COVID-19 patients. |Adult[MESH] |Angiotensin-Converting Enzyme 2/metabolism[MESH] |Antibodies, Neutralizing/*blood/immunology[MESH] |Antibodies, Viral/*blood/immunology[MESH] |Asymptomatic Infections[MESH] |COVID-19 Nucleic Acid Testing[MESH] |COVID-19/diagnosis/*immunology/physiopathology[MESH] |Coronavirus Nucleocapsid Proteins/chemistry/*immunology[MESH] |Female[MESH] |Humans[MESH] |Immunoglobulin G/blood/immunology[MESH] |Japan[MESH] |Male[MESH] |Middle Aged[MESH] |Phosphoproteins/chemistry/immunology[MESH] |Protein Domains[MESH] |SARS-CoV-2/*immunology[MESH] |Severity of Illness Index[MESH]Incomplete humoral response including neutralizing antibodies in asymp(epmc).pdf DeepDyve Pubget Overpricing