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10.1016/j.ijid.2021.01.016 http://scihub22266oqcxt.onion/10.1016/j.ijid.2021.01.016 33450372!7833601!33450372     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Infect+Dis 2021 ; 104 (ä): 415-422 Nephropedia Template TP {{tp|p=33450372|t=2021. Clinical applications of detecting IgG, IgM or IgA antibody for the diagnosis of COVID-19: A meta-analysis and systematic review |pdf=|usr=}}{{33450372}} gab.com Text Clinical applications of detecting IgG, IgM or IgA antibody for the diagnosis of COVID-19: A meta-analysis and systematic review JO: Int J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=33450372 #FOAvip BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has had a devastating impact worldwide, and timely detection and quarantine of infected patients are critical to prevent spread of disease. Serological antibody testing is an important diagnostic method used increasingly in clinics, although its clinical application is still under investigation. METHODS: A meta-analysis was conducted to compare the diagnostic performance of severe acute respiratory syndrome coronavirus-2 antibody tests in patients with COVID-19. The test results analysed included: (1) IgM-positive but IgG-negative (IgM(+)IgG(-)); (2) IgG-positive but IgM-negative (IgG(+)IgM(-)); (3) both IgM-positive and IgG-positive (IgM(+)IgG(+)); (4) IgM-positive without IgG information (IgM(+)IgG(+/-)); (5) IgG-positive without IgM information (IgG(+)IgM(+/-)); (6) either IgM-positive or IgG-positive (IgM(+) or IgG(+)); and (7) IgA-positive (IgA(+)). RESULTS: Sixty-eight studies were included. Pooled sensitivities for IgM(+)IgG(-), IgG(+)IgM(-), IgM(+)IgG(+), IgM(+)IgG(+/-), IgG(+)IgM(+/-), and IgM(+) or IgG(+) were 6%, 7%, 53%, 68%, 73% and 79% respectively. Pooled specificities ranged from 98% to 100%. IgA(+) had a pooled sensitivity of 78% but a relatively low specificity of 88%. Tests conducted 2 weeks after symptom onset showed better diagnostic accuracy than tests conducted earlier. Chemiluminescence immunoassay and detection of S protein as the antigen could offer more accurate diagnostic results. DISCUSSION: These findings support the supplemental role of serological antibody tests in the diagnosis of COVID-19. However, their capacity to diagnose COVID-19 early in the disease course could be limited. Twit Text FOAVip Clinical applications of detecting IgG, IgM or IgA antibody for the diagnosis of COVID-19: A meta-analysis and systematic review ????Int J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=33450372 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33450372 #FOAvip English Wikipedia <ref>{{Cite pmid|33450372}}</ref> Clinical applications of detecting IgG, IgM or IgA antibody for the diagnosis of COVID-19: A meta-analysis and systematic review #MMPMID33450372 Chen M; Qin R; Jiang M; Yang Z; Wen W; Li J Int J Infect Dis 2021[Mar]; 104 (ä): 415-422 PMID33450372show ga BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has had a devastating impact worldwide, and timely detection and quarantine of infected patients are critical to prevent spread of disease. Serological antibody testing is an important diagnostic method used increasingly in clinics, although its clinical application is still under investigation. METHODS: A meta-analysis was conducted to compare the diagnostic performance of severe acute respiratory syndrome coronavirus-2 antibody tests in patients with COVID-19. The test results analysed included: (1) IgM-positive but IgG-negative (IgM(+)IgG(-)); (2) IgG-positive but IgM-negative (IgG(+)IgM(-)); (3) both IgM-positive and IgG-positive (IgM(+)IgG(+)); (4) IgM-positive without IgG information (IgM(+)IgG(+/-)); (5) IgG-positive without IgM information (IgG(+)IgM(+/-)); (6) either IgM-positive or IgG-positive (IgM(+) or IgG(+)); and (7) IgA-positive (IgA(+)). RESULTS: Sixty-eight studies were included. Pooled sensitivities for IgM(+)IgG(-), IgG(+)IgM(-), IgM(+)IgG(+), IgM(+)IgG(+/-), IgG(+)IgM(+/-), and IgM(+) or IgG(+) were 6%, 7%, 53%, 68%, 73% and 79% respectively. Pooled specificities ranged from 98% to 100%. IgA(+) had a pooled sensitivity of 78% but a relatively low specificity of 88%. Tests conducted 2 weeks after symptom onset showed better diagnostic accuracy than tests conducted earlier. Chemiluminescence immunoassay and detection of S protein as the antigen could offer more accurate diagnostic results. DISCUSSION: These findings support the supplemental role of serological antibody tests in the diagnosis of COVID-19. However, their capacity to diagnose COVID-19 early in the disease course could be limited. |*Pandemics[MESH] |Antibodies, Viral/*blood[MESH] |COVID-19 Serological Testing[MESH] |COVID-19/*diagnosis/virology[MESH] |Humans[MESH] |Immunoglobulin A/blood[MESH] |Immunoglobulin G/blood[MESH] |Immunoglobulin M/blood[MESH] |Luminescent Measurements[MESH] |SARS-CoV-2/*immunology[MESH] |Sensitivity and Specificity[MESH] |Serologic Tests[MESH]Clinical applications of detecting IgG, IgM or IgA antibody for the di(epmc).pdf DeepDyve Pubget Overpricing