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10.1016/j.stem.2020.12.018 http://scihub22266oqcxt.onion/10.1016/j.stem.2020.12.018 33450186!7832490!33450186     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Stem+Cell 2021 ; 28 (2): 331-342.e5 Nephropedia Template TP {{tp|p=33450186|t=2021. ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response |pdf=|usr=}}{{33450186}} gab.com Text ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response JO: Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=33450186 #FOAvip ApoE4, a strong genetic risk factor for Alzheimer disease, has been associated with increased risk for severe COVID-19. However, it is unclear whether ApoE4 alters COVID-19 susceptibility or severity, and the role of direct viral infection in brain cells remains obscure. We tested the neurotropism of SARS-CoV2 in human-induced pluripotent stem cell (hiPSC) models and observed low-grade infection of neurons and astrocytes that is boosted in neuron-astrocyte co-cultures and organoids. We then generated isogenic ApoE3/3 and ApoE4/4 hiPSCs and found an increased rate of SARS-CoV-2 infection in ApoE4/4 neurons and astrocytes. ApoE4 astrocytes exhibited enlarged size and elevated nuclear fragmentation upon SARS-CoV-2 infection. Finally, we show that remdesivir treatment inhibits SARS-CoV2 infection of hiPSC neurons and astrocytes. These findings suggest that ApoE4 may play a causal role in COVID-19 severity. Understanding how risk factors impact COVID-19 susceptibility and severity will help us understand the potential long-term effects in different patient populations. Twit Text FOAVip ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response ????Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=33450186 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33450186 #FOAvip English Wikipedia <ref>{{Cite pmid|33450186}}</ref> ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response #MMPMID33450186 Wang C; Zhang M; Garcia G Jr; Tian E; Cui Q; Chen X; Sun G; Wang J; Arumugaswami V; Shi Y Cell Stem Cell 2021[Feb]; 28 (2): 331-342.e5 PMID33450186show ga ApoE4, a strong genetic risk factor for Alzheimer disease, has been associated with increased risk for severe COVID-19. However, it is unclear whether ApoE4 alters COVID-19 susceptibility or severity, and the role of direct viral infection in brain cells remains obscure. We tested the neurotropism of SARS-CoV2 in human-induced pluripotent stem cell (hiPSC) models and observed low-grade infection of neurons and astrocytes that is boosted in neuron-astrocyte co-cultures and organoids. We then generated isogenic ApoE3/3 and ApoE4/4 hiPSCs and found an increased rate of SARS-CoV-2 infection in ApoE4/4 neurons and astrocytes. ApoE4 astrocytes exhibited enlarged size and elevated nuclear fragmentation upon SARS-CoV-2 infection. Finally, we show that remdesivir treatment inhibits SARS-CoV2 infection of hiPSC neurons and astrocytes. These findings suggest that ApoE4 may play a causal role in COVID-19 severity. Understanding how risk factors impact COVID-19 susceptibility and severity will help us understand the potential long-term effects in different patient populations. |Adenosine Monophosphate/analogs & derivatives/pharmacology[MESH] |Alanine/analogs & derivatives/pharmacology[MESH] |Animals[MESH] |Antiviral Agents/pharmacology[MESH] |Apolipoproteins E/*metabolism[MESH] |Astrocytes/drug effects/pathology/virology[MESH] |Brain/*pathology/*virology[MESH] |COVID-19/*virology[MESH] |Cell Differentiation[MESH] |Chlorocebus aethiops[MESH] |Humans[MESH] |Induced Pluripotent Stem Cells/*virology[MESH] |Nerve Degeneration/pathology[MESH] |Neurites/pathology[MESH] |Neurons/drug effects/pathology/virology[MESH] |Organoids/drug effects/pathology/virology[MESH] |Protein Isoforms/metabolism[MESH] |SARS-CoV-2/*physiology[MESH] |Synapses/pathology[MESH] |Tropism/*physiology[MESH]ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response (epmc).pdf DeepDyve Pubget Overpricing