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10.5578/tt.70351

http://scihub22266oqcxt.onion/10.5578/tt.70351
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33448732!ä!33448732

suck abstract from ncbi


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pmid33448732      Tuberk+Toraks 2020 ; 68 (4): 353-360
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  • D-dimer seviyeleri ve COVID-19 siddeti: Sistematik Derleme ve Meta-analiz #MMPMID33448732
  • Duz ME; Balci A; Menekse E
  • Tuberk Toraks 2020[Dec]; 68 (4): 353-360 PMID33448732show ga
  • INTRODUCTION: Coronavirus disease 2019 (COVID-19) is a fatal and pandemic disease discovered in December 2019 in Wuhan, with lots of asymptomatic cases and a long incubation period. The researchers suggested that high d-dimer levels could predict disease severity, lung complications, and thromboembolic events before they occur. MATERIALS AND METHODS: We searched in PubMed, Scopus, and Web of Science using the keywords "D-dimer" and "coronavirus" or "D-dimer" and "COVID-19." We used Standardized Mean Differences (SMD) to build forest plots of continuous data and assess differences in serum D-dimer concentrations between severe and non-severe patients with COVID-19 disease. We evaluated p-value < 0.05 as statistically significant and preferred 95% confidence intervals (CIs). RESULT: The pooled results of all studies revealed that the D-dimer concentrations were significantly higher in patients with more severe COVID-19 (SMD: 2.32 mug/mL; 95% CI, 0.72 3.92 mug/mL, p< 0.001). We evaluated severe patients with total D-dimer levels. D-dimer concentrations were significantly higher in severe patients against total COVID-19 patients (SMD: 2.01 mug/mL; 95% CI, 0.25 to 3.77 mug/mL, p= 0.08). CONCLUSIONS: We do not know the D-dimer increment mechanism in severe patients yet, but we think that these findings will be useful in the early diagnosis of severe disease and the first treatment.
  • |*SARS-CoV-2[MESH]
  • |Biomarkers/blood[MESH]
  • |COVID-19/blood/diagnosis/*epidemiology[MESH]
  • |Fibrin Fibrinogen Degradation Products/*metabolism[MESH]
  • |Humans[MESH]


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