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10.1111/jth.15032

http://scihub22266oqcxt.onion/10.1111/jth.15032
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33448631!9770966!33448631
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suck abstract from ncbi


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pmid33448631      J+Thromb+Haemost 2020 ; 18 (10): 2640-2645
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  • Chronic therapeutic anticoagulation is associated with decreased thrombotic complications in SARS-CoV-2 infection #MMPMID33448631
  • Lachant DJ; Lachant NA; Kouides P; Rappaport S; Prasad P; White RJ
  • J Thromb Haemost 2020[Oct]; 18 (10): 2640-2645 PMID33448631show ga
  • BACKGROUND: Thrombotic disease complicates severe SARS-CoV-2 infection and is associated with increased morbidity and mortality. Various anticoagulation strategies have been evaluated in hospitalized patients to prevent complications. The impact of chronic anticoagulation before SARS-CoV-2 infection on the risk for subsequent thrombosis has not been systematically studied. METHODS: This was a retrospective single-center study. All patients with positive SARS-CoV-2 PCR testing from March 13, 2020, through May 6, 2020, at the University of Rochester Medical Center were identified. We included all patients receiving therapeutic anticoagulation for at least 1 month before COVID diagnosis. We documented the rate of thrombotic complications, type of anticoagulation, bleeding complications, and mortality. RESULTS: A total of 107 SARS-CoV2-infected patients were chronically anticoagulated before SARS-CoV-2 testing with a median age of 78. Of those, 42 required hospital admission, with 17 requiring intensive care. No patients, inpatient or outpatient, were diagnosed with a new symptomatic thrombotic complication. Three patients had minor bleeding in the hospital. Thirteen (12%) patients died (69% male). CONCLUSION: Our uncontrolled findings suggest that chronic anticoagulation at the time of infection may protect against thrombotic complications and decrease disease severity.
  • |*COVID-19 Drug Treatment[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Anticoagulants/administration & dosage/adverse effects/*therapeutic use[MESH]
  • |COVID-19/*complications/mortality[MESH]
  • |Female[MESH]
  • |Hemorrhage/etiology[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |New York/epidemiology[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]


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