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10.12688/f1000research.25842.2 http://scihub22266oqcxt.onion/10.12688/f1000research.25842.2 33447376!7783530!33447376     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       F1000Res 2020 ; 9 (ä): 1017 Nephropedia Template TP {{tp|p=33447376|t=2020. Effects of rapid recruitment and dissemination on Covid-19 mortality: the RECOVERY trial |pdf=|usr=}}{{33447376}} gab.com Text Effects of rapid recruitment and dissemination on Covid-19 mortality: the RECOVERY trial JO: F1000Res http://www.kidney.de/pget.php?&tw=1&pmid=33447376 #FOAvip The RECOVERY trial is a large multi-armed, adaptive randomised controlled trial of treatments for Covid-19. It has rapidly recruited and demonstrated that hydroxychloroquine is ineffective in reducing mortality for hospitalised patients, whilst dexamethasone significantly reduces mortality among those patients using supplemental oxygen or on a ventilator. We estimate that the speed of recruitment and dissemination has probably decreased mortality in the UK by at least 200 hospitalised patients in the first month since the British Prime Minister announced the results. Despite its impressive speed, the trial only recruited about 10-15% of eligible patients, with recruitment rates ranging between 3% to 80% at participating hospitals. Had the trial recruited 50% of the eligible patients then our analysis suggests that more than 2,000 additional lives could have been saved. In a pandemic, rapid recruitment with high centre recruitment is absolutely essential to reduce deaths. Methods of improving site specific recruitment rates need investigating urgently. Twit Text FOAVip Effects of rapid recruitment and dissemination on Covid-19 mortality: the RECOVERY trial ????F1000Res http://www.kidney.de/pget.php?&tw=1&pmid=33447376 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33447376 #FOAvip English Wikipedia <ref>{{Cite pmid|33447376}}</ref> Effects of rapid recruitment and dissemination on Covid-19 mortality: the RECOVERY trial #MMPMID33447376 Knowlson C; Torgerson DJ F1000Res 2020[]; 9 (ä): 1017 PMID33447376show ga The RECOVERY trial is a large multi-armed, adaptive randomised controlled trial of treatments for Covid-19. It has rapidly recruited and demonstrated that hydroxychloroquine is ineffective in reducing mortality for hospitalised patients, whilst dexamethasone significantly reduces mortality among those patients using supplemental oxygen or on a ventilator. We estimate that the speed of recruitment and dissemination has probably decreased mortality in the UK by at least 200 hospitalised patients in the first month since the British Prime Minister announced the results. Despite its impressive speed, the trial only recruited about 10-15% of eligible patients, with recruitment rates ranging between 3% to 80% at participating hospitals. Had the trial recruited 50% of the eligible patients then our analysis suggests that more than 2,000 additional lives could have been saved. In a pandemic, rapid recruitment with high centre recruitment is absolutely essential to reduce deaths. Methods of improving site specific recruitment rates need investigating urgently. |*Patient Selection[MESH] |COVID-19/*mortality/therapy[MESH] |Dexamethasone/therapeutic use[MESH] |Humans[MESH] |Hydroxychloroquine[MESH] |Multicenter Studies as Topic[MESH] |Pandemics[MESH] |Randomized Controlled Trials as Topic[MESH] |Treatment Outcome[MESH]Effects of rapid recruitment and dissemination on Covid-19 mortality: (epmc).pdf DeepDyve Pubget Overpricing