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10.1186/s12879-021-05773-w

http://scihub22266oqcxt.onion/10.1186/s12879-021-05773-w
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33446136!7807228!33446136
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suck abstract from ncbi


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pmid33446136      BMC+Infect+Dis 2021 ; 21 (1): 72
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  • Hydroxychloroquine in the treatment of outpatients with mildly symptomatic COVID-19: a multi-center observational study #MMPMID33446136
  • Ip A; Ahn J; Zhou Y; Goy AH; Hansen E; Pecora AL; Sinclaire BA; Bednarz U; Marafelias M; Sawczuk IS; Underwood JP 3rd; Walker DM; Prasad R; Sweeney RL; Ponce MG; La Capra S; Cunningham FJ; Calise AG; Pulver BL; Ruocco D; Mojares GE; Eagan MP; Ziontz KL; Mastrokyriakos P; Goldberg SL
  • BMC Infect Dis 2021[Jan]; 21 (1): 72 PMID33446136show ga
  • BACKGROUND: Hydroxychloroquine has not been associated with improved survival among hospitalized COVID-19 patients in the majority of observational studies and similarly was not identified as an effective prophylaxis following exposure in a prospective randomized trial. We aimed to explore the role of hydroxychloroquine therapy in mildly symptomatic patients diagnosed in the outpatient setting. METHODS: We examined the association between outpatient hydroxychloroquine exposure and the subsequent progression of disease among mildly symptomatic non-hospitalized patients with documented SARS-CoV-2 infection. The primary outcome assessed was requirement of hospitalization. Data was obtained from a retrospective review of electronic health records within a New Jersey USA multi-hospital network. We compared outcomes in patients who received hydroxychloroquine with those who did not applying a multivariable logistic model with propensity matching. RESULTS: Among 1274 outpatients with documented SARS-CoV-2 infection 7.6% were prescribed hydroxychloroquine. In a 1067 patient propensity matched cohort, 21.6% with outpatient exposure to hydroxychloroquine were hospitalized, and 31.4% without exposure were hospitalized. In the primary multivariable logistic regression analysis with propensity matching there was an association between exposure to hydroxychloroquine and a decreased rate of hospitalization from COVID-19 (OR 0.53; 95% CI, 0.29, 0.95). Sensitivity analyses revealed similar associations. QTc prolongation events occurred in 2% of patients prescribed hydroxychloroquine with no reported arrhythmia events among those with data available. CONCLUSIONS: In this retrospective observational study of SARS-CoV-2 infected non-hospitalized patients hydroxychloroquine exposure was associated with a decreased rate of subsequent hospitalization. Additional exploration of hydroxychloroquine in this mildly symptomatic outpatient population is warranted.
  • |*COVID-19 Drug Treatment[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |COVID-19/virology[MESH]
  • |Female[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/*administration & dosage[MESH]
  • |Logistic Models[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |New Jersey[MESH]
  • |Outpatients/statistics & numerical data[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2/drug effects/genetics/physiology[MESH]


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