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10.1371/journal.pone.0245547

http://scihub22266oqcxt.onion/10.1371/journal.pone.0245547
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33444422!7808673!33444422
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suck abstract from ncbi


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pmid33444422      PLoS+One 2021 ; 16 (1): e0245547
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  • Clinical and radiological findings of adult hospitalized patients with community-acquired pneumonia from SARS-CoV-2 and endemic human coronaviruses #MMPMID33444422
  • Baek MS; Cha MJ; Kim MC; Chung JW; Kim WY; Choi H; Choi SH
  • PLoS One 2021[]; 16 (1): e0245547 PMID33444422show ga
  • Endemic human coronaviruses (HCoVs) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are members of the family Coronaviridae. Comparing the findings of the infections caused by these viruses would help reveal the novel characteristics of SARS-CoV-2 and provide insight into the unique pathogenesis of SARS-CoV-2 infection. This study aimed to compare the clinical and radiological characteristics of SARS-CoV-2 and endemic HCoVs infection in adult hospitalized patients with community-acquired pneumonia (CAP). This study was performed at a university-affiliated tertiary hospital in the Republic of Korea, between January 1, 2015, and July 31, 2020. A total of 109 consecutive patients who were over 18 years of age with confirmed SARS-CoV-2 and endemic HCoVs were enrolled. Finally, 19 patients with SARS-CoV-2 CAP were compared to 40 patients with endemic HCoV CAP. Flu-like symptoms such as cough, sore throat, headache, myalgia, and prolonged fever were more common in SARS-CoV-2 CAP, whereas clinical findings suggestive of bacterial pneumonia such as dyspnea, leukocytosis with left shift, and increased C-reactive protein were more common in endemic HCoV CAP. Bilateral peripherally distributed ground-glass opacities (GGOs) were typical radiologic findings in SARS-CoV-2 CAP, whereas mixed patterns of GGOs, consolidations, micronodules, and pleural effusion were observed in endemic HCoV CAP. Coinfection was not observed in patients with SARS-CoV-2 CAP, but was observed in more than half of the patients with endemic HCoV CAP. There were distinctive differences in the clinical and radiologic findings between SARS-CoV-2 and endemic HCoV CAP. Further investigations are required to elucidate the mechanism underlying this difference. Follow-up observations are needed to determine if the presentation of SARS-CoV-2 CAP changes with repeated infection.
  • |Aged[MESH]
  • |COVID-19/*diagnostic imaging/epidemiology/pathology/virology[MESH]
  • |Cohort Studies[MESH]
  • |Coinfection/diagnostic imaging/epidemiology/pathology/virology[MESH]
  • |Community-Acquired Infections[MESH]
  • |Coronavirus/isolation & purification[MESH]
  • |Endemic Diseases[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Lung/diagnostic imaging[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Middle East Respiratory Syndrome Coronavirus/isolation & purification[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*diagnostic imaging/epidemiology/pathology/virology[MESH]
  • |Radiography, Thoracic/methods[MESH]
  • |Republic of Korea/epidemiology[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2/isolation & purification[MESH]


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