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10.1172/jci.insight.143299 http://scihub22266oqcxt.onion/10.1172/jci.insight.143299 33444289!7934921!33444289     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       JCI+Insight 2021 ; 6 (4): ä Nephropedia Template TP {{tp|p=33444289|t=2021. Circulating mitochondrial DNA is an early indicator of severe illness and mortality from COVID-19 |pdf=|usr=}}{{33444289}} gab.com Text Circulating mitochondrial DNA is an early indicator of severe illness and mortality from COVID-19 JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=33444289 #FOAvip BackgroundMitochondrial DNA (MT-DNA) are intrinsically inflammatory nucleic acids released by damaged solid organs. Whether circulating cell-free MT-DNA quantitation could be used to predict the risk of poor COVID-19 outcomes remains undetermined.MethodsWe measured circulating MT-DNA levels in prospectively collected, cell-free plasma samples from 97 subjects with COVID-19 at hospital presentation. Our primary outcome was mortality. Intensive care unit (ICU) admission, intubation, vasopressor, and renal replacement therapy requirements were secondary outcomes. Multivariate regression analysis determined whether MT-DNA levels were independent of other reported COVID-19 risk factors. Receiver operating characteristic and area under the curve assessments were used to compare MT-DNA levels with established and emerging inflammatory markers of COVID-19.ResultsCirculating MT-DNA levels were highly elevated in patients who eventually died or required ICU admission, intubation, vasopressor use, or renal replacement therapy. Multivariate regression revealed that high circulating MT-DNA was an independent risk factor for these outcomes after adjusting for age, sex, and comorbidities. We also found that circulating MT-DNA levels had a similar or superior area under the curve when compared against clinically established measures of inflammation and emerging markers currently of interest as investigational targets for COVID-19 therapy.ConclusionThese results show that high circulating MT-DNA levels are a potential early indicator for poor COVID-19 outcomes.FundingWashington University Institute of Clinical Translational Sciences COVID-19 Research Program and Washington University Institute of Clinical Translational Sciences (ICTS) NIH grant UL1TR002345. Twit Text FOAVip Circulating mitochondrial DNA is an early indicator of severe illness and mortality from COVID-19 ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=33444289 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33444289 #FOAvip English Wikipedia <ref>{{Cite pmid|33444289}}</ref> Circulating mitochondrial DNA is an early indicator of severe illness and mortality from COVID-19 #MMPMID33444289 Scozzi D; Cano M; Ma L; Zhou D; Zhu JH; O'Halloran JA; Goss C; Rauseo AM; Liu Z; Sahu SK; Peritore V; Rocco M; Ricci A; Amodeo R; Aimati L; Ibrahim M; Hachem R; Kreisel D; Mudd PA; Kulkarni HS; Gelman AE JCI Insight 2021[Feb]; 6 (4): ä PMID33444289show ga BackgroundMitochondrial DNA (MT-DNA) are intrinsically inflammatory nucleic acids released by damaged solid organs. Whether circulating cell-free MT-DNA quantitation could be used to predict the risk of poor COVID-19 outcomes remains undetermined.MethodsWe measured circulating MT-DNA levels in prospectively collected, cell-free plasma samples from 97 subjects with COVID-19 at hospital presentation. Our primary outcome was mortality. Intensive care unit (ICU) admission, intubation, vasopressor, and renal replacement therapy requirements were secondary outcomes. Multivariate regression analysis determined whether MT-DNA levels were independent of other reported COVID-19 risk factors. Receiver operating characteristic and area under the curve assessments were used to compare MT-DNA levels with established and emerging inflammatory markers of COVID-19.ResultsCirculating MT-DNA levels were highly elevated in patients who eventually died or required ICU admission, intubation, vasopressor use, or renal replacement therapy. Multivariate regression revealed that high circulating MT-DNA was an independent risk factor for these outcomes after adjusting for age, sex, and comorbidities. We also found that circulating MT-DNA levels had a similar or superior area under the curve when compared against clinically established measures of inflammation and emerging markers currently of interest as investigational targets for COVID-19 therapy.ConclusionThese results show that high circulating MT-DNA levels are a potential early indicator for poor COVID-19 outcomes.FundingWashington University Institute of Clinical Translational Sciences COVID-19 Research Program and Washington University Institute of Clinical Translational Sciences (ICTS) NIH grant UL1TR002345. |*Severity of Illness Index[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Biomarkers/blood[MESH] |COVID-19/*diagnosis/mortality/therapy/virology[MESH] |Cell-Free Nucleic Acids/*blood[MESH] |DNA, Mitochondrial/*blood[MESH] |Female[MESH] |Follow-Up Studies[MESH] |Hospital Mortality[MESH] |Humans[MESH] |Intensive Care Units/statistics & numerical data[MESH] |Male[MESH] |Middle Aged[MESH] |Prospective Studies[MESH] |ROC Curve[MESH] |Renal Replacement Therapy/statistics & numerical data[MESH] |Respiration, Artificial/statistics & numerical data[MESH] |Risk Factors[MESH] |SARS-CoV-2/isolation & purification[MESH]Circulating mitochondrial DNA is an early indicator of severe illness (epmc).pdf DeepDyve Pubget Overpricing