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Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Am+J+Transplant 2021 ; 21 (7): 2522-2531 Nephropedia Template TP
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An early experience on the effect of solid organ transplant status on hospitalized COVID-19 patients #MMPMID33443778
Nair V; Jandovitz N; Hirsch JS; Abate M; Satapathy SK; Roth N; Miyara SJ; Guevara S; Kressel AM; Xiang A; Wu G; Butensky SD; Lin D; Williams S; Bhaskaran MC; Majure DT; Grodstein E; Lau L; Nair G; Fahmy AE; Winnick A; Breslin N; Berlinrut I; Molmenti C; Becker LB; Malhotra P; Gautam-Goyal P; Lima B; Maybaum S; Shah SK; Takegawa R; Hayashida K; Shinozaki K; Teperman LW; Molmenti EP
Am J Transplant 2021[Jul]; 21 (7): 2522-2531 PMID33443778show ga
We compared the outcome of COVID-19 in immunosuppressed solid organ transplant (SOT) patients to a transplant naive population. In total, 10 356 adult hospital admissions for COVID-19 from March 1, 2020 to April 27, 2020 were analyzed. Data were collected on demographics, baseline clinical conditions, medications, immunosuppression, and COVID-19 course. Primary outcome was combined death or mechanical ventilation. We assessed the association between primary outcome and prognostic variables using bivariate and multivariate regression models. We also compared the primary endpoint in SOT patients to an age, gender, and comorbidity-matched control group. Bivariate analysis found transplant status, age, gender, race/ethnicity, body mass index, diabetes, hypertension, cardiovascular disease, COPD, and GFR <60 mL/min/1.73 m(2) to be significant predictors of combined death or mechanical ventilation. After multivariate logistic regression analysis, SOT status had a trend toward significance (odds ratio [OR] 1.29; 95% CI 0.99-1.69, p = .06). Compared to an age, gender, and comorbidity-matched control group, SOT patients had a higher combined risk of death or mechanical ventilation (OR 1.34; 95% CI 1.03-1.74, p = .027).