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10.1039/d0cc08265a

http://scihub22266oqcxt.onion/10.1039/d0cc08265a
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33443248!8120452!33443248
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suck abstract from ncbi


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pmid33443248      Chem+Commun+(Camb) 2021 ; 57 (12): 1474-1477
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  • Synthesis and immunological evaluation of synthetic peptide based anti-SARS-CoV-2 vaccine candidates #MMPMID33443248
  • Zhao Q; Gao Y; Xiao M; Huang X; Wu X
  • Chem Commun (Camb) 2021[Feb]; 57 (12): 1474-1477 PMID33443248show ga
  • For prevention of the coronavirus disease 2019 caused by the novel coronavirus SARS-CoV-2, an effective vaccine is critical. Herein, several potential peptide epitopes from the spike protein of SARS-CoV-2 have been synthesized and covalently linked with the cross-reactive material (CRM197). Immunization of mice with the resulting conjugates induced high titers of IgG antibodies against the spike protein. Importantly, the post-immune sera effectively neutralized SARS-CoV-2 pseudovirus, suggesting the epitopes identified are protective, and these conjugates are promising leads for anti-SARS-CoV-2 vaccine development.
  • |COVID-19 Vaccines/*chemical synthesis/*immunology[MESH]
  • |Cross Reactions[MESH]
  • |Immunoglobulin G/immunology[MESH]
  • |SARS-CoV-2/*immunology[MESH]
  • |Spike Glycoprotein, Coronavirus/immunology[MESH]


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