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Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Chem+Commun+(Camb) 2021 ; 57 (12): 1474-1477 Nephropedia Template TP
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Synthesis and immunological evaluation of synthetic peptide based anti-SARS-CoV-2 vaccine candidates #MMPMID33443248
Zhao Q; Gao Y; Xiao M; Huang X; Wu X
Chem Commun (Camb) 2021[Feb]; 57 (12): 1474-1477 PMID33443248show ga
For prevention of the coronavirus disease 2019 caused by the novel coronavirus SARS-CoV-2, an effective vaccine is critical. Herein, several potential peptide epitopes from the spike protein of SARS-CoV-2 have been synthesized and covalently linked with the cross-reactive material (CRM197). Immunization of mice with the resulting conjugates induced high titers of IgG antibodies against the spike protein. Importantly, the post-immune sera effectively neutralized SARS-CoV-2 pseudovirus, suggesting the epitopes identified are protective, and these conjugates are promising leads for anti-SARS-CoV-2 vaccine development.