Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi


10.3390/v13010090

http://scihub22266oqcxt.onion/10.3390/v13010090
suck pdf from google scholar
33440724!7826519!33440724
unlimited free pdf from europmc33440724    free
PDF from PMC    free
html from PMC    free

Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33440724&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215

suck abstract from ncbi

pmid33440724      Viruses 2021 ; 13 (1): ä
Nephropedia Template TP

gab.com Text

Twit Text FOAVip

Twit Text #

English Wikipedia


  • The Fatty Acid Lipid Metabolism Nexus in COVID-19 #MMPMID33440724
  • Tanner JE; Alfieri C
  • Viruses 2021[Jan]; 13 (1): ä PMID33440724show ga
  • Enteric symptomology seen in early-stage severe acute respiratory syndrome (SARS)-2003 and COVID-19 is evidence of virus replication occurring in the intestine, liver and pancreas. Aberrant lipid metabolism in morbidly obese individuals adversely affects the COVID-19 immune response and increases disease severity. Such observations are in line with the importance of lipid metabolism in COVID-19, and point to the gut as a site for intervention as well as a therapeutic target in treating the disease. Formation of complex lipid membranes and palmitoylation of coronavirus proteins are essential during viral replication and assembly. Inhibition of fatty acid synthase (FASN) and restoration of lipid catabolism by activation of AMP-activated protein kinase (AMPK) impede replication of coronaviruses closely related to SARS-coronavirus-2 (CoV-2). In vitro findings and clinical data reveal that the FASN inhibitor, orlistat, and the AMPK activator, metformin, may inhibit coronavirus replication and reduce systemic inflammation to restore immune homeostasis. Such observations, along with the known mechanisms of action for these types of drugs, suggest that targeting fatty acid lipid metabolism could directly inhibit virus replication while positively impacting the patient's response to COVID-19.
  • |*Lipid Metabolism[MESH]
  • |AMP-Activated Protein Kinases/metabolism/pharmacology[MESH]
  • |Antiviral Agents/pharmacology/therapeutic use[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |COVID-19/*metabolism/virology[MESH]
  • |Digestive System/drug effects/virology[MESH]
  • |Fatty Acid Synthases/antagonists & inhibitors/metabolism[MESH]
  • |Fatty Acids/*metabolism[MESH]
  • |Humans[MESH]
  • |Metformin/therapeutic use[MESH]
  • |Obesity/drug therapy/metabolism/virology[MESH]
  • |Orlistat/therapeutic use[MESH]
  • |SARS-CoV-2/drug effects/*physiology[MESH]
  • |Viral Proteins/metabolism[MESH]
  • |Virus Assembly/drug effects[MESH]


  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    Linkout box