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10.1016/j.celrep.2020.108616 http://scihub22266oqcxt.onion/10.1016/j.celrep.2020.108616 33440155!7869691!33440155     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2021 ; 34 (2): 108616 Nephropedia Template TP {{tp|p=33440155|t=2021. Magnesium and Calcium Homeostasis Depend on KCTD1 Function in the Distal Nephron |pdf=|usr=}}{{33440155}} gab.com Text Magnesium and Calcium Homeostasis Depend on KCTD1 Function in the Distal Nephron JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=33440155 #FOAvip Magnesium (Mg(2+)) homeostasis depends on active transcellular Mg(2+) reuptake from urine in distal convoluted tubules (DCTs) via the Mg(2+) channel TRPM6, whose activity has been proposed to be regulated by EGF. Calcium (Ca(2+)) homeostasis depends on paracellular reabsorption in the thick ascending limbs of Henle (TALs). KCTD1 promotes terminal differentiation of TALs/DCTs, but how its deficiency affects urinary Mg(2+) and Ca(2+) reabsorption is unknown. Here, this study shows that DCT1-specific KCTD1 inactivation leads to hypomagnesemia despite normal TRPM6 levels because of reduced levels of the sodium chloride co-transporter NCC, whereas Mg(2+) homeostasis does not depend on EGF. Moreover, KCTD1 deficiency impairs paracellular urinary Ca(2+) and Mg(2+) reabsorption in TALs because of reduced NKCC2/claudin-16/-19 and increased claudin-14 expression, leading to hypocalcemia and consequently to secondary hyperparathyroidism and progressive metabolic bone disease. Thus, KCTD1 regulates urinary reabsorption of Mg(2+) and Ca(2+) by inducing expression of NCC in DCTs and NKCC2/claudin-16/-19 in TALs. Twit Text FOAVip Magnesium and Calcium Homeostasis Depend on KCTD1 Function in the Distal Nephron ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=33440155 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33440155 #FOAvip English Wikipedia <ref>{{Cite pmid|33440155}}</ref> Magnesium and Calcium Homeostasis Depend on KCTD1 Function in the Distal Nephron #MMPMID33440155 Marneros AG Cell Rep 2021[Jan]; 34 (2): 108616 PMID33440155show ga Magnesium (Mg(2+)) homeostasis depends on active transcellular Mg(2+) reuptake from urine in distal convoluted tubules (DCTs) via the Mg(2+) channel TRPM6, whose activity has been proposed to be regulated by EGF. Calcium (Ca(2+)) homeostasis depends on paracellular reabsorption in the thick ascending limbs of Henle (TALs). KCTD1 promotes terminal differentiation of TALs/DCTs, but how its deficiency affects urinary Mg(2+) and Ca(2+) reabsorption is unknown. Here, this study shows that DCT1-specific KCTD1 inactivation leads to hypomagnesemia despite normal TRPM6 levels because of reduced levels of the sodium chloride co-transporter NCC, whereas Mg(2+) homeostasis does not depend on EGF. Moreover, KCTD1 deficiency impairs paracellular urinary Ca(2+) and Mg(2+) reabsorption in TALs because of reduced NKCC2/claudin-16/-19 and increased claudin-14 expression, leading to hypocalcemia and consequently to secondary hyperparathyroidism and progressive metabolic bone disease. Thus, KCTD1 regulates urinary reabsorption of Mg(2+) and Ca(2+) by inducing expression of NCC in DCTs and NKCC2/claudin-16/-19 in TALs. |Animals[MESH] |Calcium/*metabolism[MESH] |Co-Repressor Proteins/*metabolism[MESH] |Homeostasis[MESH] |Humans[MESH] |Magnesium/*metabolism[MESH] |Male[MESH] |Mice[MESH] |Nephrons/*metabolism[MESH]Magnesium and Calcium Homeostasis Depend on KCTD1 Function in the Dist(epmc).pdf DeepDyve Pubget Overpricing