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10.1016/j.celrep.2020.108628 http://scihub22266oqcxt.onion/10.1016/j.celrep.2020.108628 33440148!7832566!33440148     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33440148&cmd=llinks): Failed to open stream: HTTP request failed! 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MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells |pdf=|usr=}}{{33440148}} gab.com Text MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=33440148 #FOAvip Recent studies have profiled the innate immune signatures in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and suggest that cellular responses to viral challenge may affect disease severity. Yet the molecular events that underlie cellular recognition and response to SARS-CoV-2 infection remain to be elucidated. Here, we find that SARS-CoV-2 replication induces a delayed interferon (IFN) response in lung epithelial cells. By screening 16 putative sensors involved in sensing of RNA virus infection, we found that MDA5 and LGP2 primarily regulate IFN induction in response to SARS-CoV-2 infection. Further analyses revealed that viral intermediates specifically activate the IFN response through MDA5-mediated sensing. Additionally, we find that IRF3, IRF5, and NF-kappaB/p65 are the key transcription factors regulating the IFN response during SARS-CoV-2 infection. In summary, these findings provide critical insights into the molecular basis of the innate immune recognition and signaling response to SARS-CoV-2. Twit Text FOAVip MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=33440148 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33440148 #FOAvip English Wikipedia <ref>{{Cite pmid|33440148}}</ref> MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells #MMPMID33440148 Yin X; Riva L; Pu Y; Martin-Sancho L; Kanamune J; Yamamoto Y; Sakai K; Gotoh S; Miorin L; De Jesus PD; Yang CC; Herbert KM; Yoh S; Hultquist JF; Garcia-Sastre A; Chanda SK Cell Rep 2021[Jan]; 34 (2): 108628 PMID33440148show ga Recent studies have profiled the innate immune signatures in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and suggest that cellular responses to viral challenge may affect disease severity. Yet the molecular events that underlie cellular recognition and response to SARS-CoV-2 infection remain to be elucidated. Here, we find that SARS-CoV-2 replication induces a delayed interferon (IFN) response in lung epithelial cells. By screening 16 putative sensors involved in sensing of RNA virus infection, we found that MDA5 and LGP2 primarily regulate IFN induction in response to SARS-CoV-2 infection. Further analyses revealed that viral intermediates specifically activate the IFN response through MDA5-mediated sensing. Additionally, we find that IRF3, IRF5, and NF-kappaB/p65 are the key transcription factors regulating the IFN response during SARS-CoV-2 infection. In summary, these findings provide critical insights into the molecular basis of the innate immune recognition and signaling response to SARS-CoV-2. |*Immunity, Innate[MESH] |COVID-19/pathology/virology[MESH] |Cell Line[MESH] |Epithelial Cells/cytology/immunology/virology[MESH] |Humans[MESH] |Induced Pluripotent Stem Cells/cytology[MESH] |Interferon Regulatory Factor-3/genetics/metabolism[MESH] |Interferon Regulatory Factors/genetics/metabolism[MESH] |Interferon-Induced Helicase, IFIH1/*metabolism[MESH] |Interferons/genetics/metabolism[MESH] |RNA Helicases/metabolism[MESH] |RNA Interference[MESH] |RNA, Double-Stranded/metabolism[MESH] |RNA, Small Interfering/metabolism[MESH] |SARS-CoV-2/immunology/isolation & purification/*physiology[MESH] |Signal Transduction[MESH] |Transcription Factor RelA/metabolism[MESH]MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epitheli(epmc).pdf DeepDyve Pubget Overpricing