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10.1007/s00330-020-07593-z

http://scihub22266oqcxt.onion/10.1007/s00330-020-07593-z
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33439316!7804574!33439316
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suck abstract from ncbi


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pmid33439316      Eur+Radiol 2021 ; 31 (7): 5172-5177
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  • Normal chest CT in 1091 symptomatic patients with confirmed Covid-19: frequency, characteristics and outcome #MMPMID33439316
  • Leonard-Lorant I; Severac F; Bilbault P; Muller J; Leyendecker P; Roy C; Ohana M
  • Eur Radiol 2021[Jul]; 31 (7): 5172-5177 PMID33439316show ga
  • OBJECTIVE: Frequency of normal chest CT in symptomatic COVID-19 patients as well as the outcome of these patients remains unknown. The objectives of this work were to assess the incidence of initially normal chest CT in a cohort of consecutive confirmed COVID-19 patients with respiratory symptoms and to compare their clinical characteristics and their outcome to matched patients with typical COVID-19 lesions at initial CT. METHODS: From March 6(th) to April 22(nd), all consecutive adult patients referred to the COVID-19 clinic of our Emergency Department were retrospectively analyzed. Each patient with a positive SARS-CoV-2 RT-PCR and a normal initial chest CT after second reading was 1:1 matched based on sex, age and date of CT acquisition to a patient with positive RT-PCR and initial chest CT with typical COVID-19 lesions. Clinical data, laboratory results and outcomes (major being mechanical ventilation and/or death) were compared between both groups, using Wilcoxon signed-rank test, McNemar's chi-squared test and/or exact McNemar's test where appropriate. RESULTS: Fifty-seven chest CT out of 1091 (5.2%, 95% CI 4.0-6.7) in symptomatic patients with positive RT-PCR were normal, with a median onset of symptoms of 4.5 days (IQR [1.25-10.25]). After a median follow-up of 43 days, death and/or mechanical ventilation occurred in 3 patients (5.3%) in the study group, versus 11 (19.3%) in the control group (p = 0.011). CONCLUSIONS: Normal initial chest CT occurred in 5.2% of symptomatic confirmed COVID-19 cases in our cohort. While better than those with abnormal chest CT, outcome was not entirely benign with 5.3% death and/or mechanical ventilation. KEY POINTS: * In a cohort of 1091 symptomatic COVID-19 patients, initial chest CT was normal in 5.2% of cases. * Normal chest CT in confirmed COVID-19 is frequent even when onset of symptoms is greater than 3 days. * The outcome of COVID-19 patients with initial normal chest CT, while better than those with abnormal CT, was not entirely benign with 5.3% death and/or mechanical ventilation.
  • |*COVID-19/diagnostic imaging[MESH]
  • |Adult[MESH]
  • |Humans[MESH]
  • |Radiography, Thoracic[MESH]
  • |Retrospective Studies[MESH]
  • |Thorax/diagnostic imaging[MESH]


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