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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Sci+Rep 2021 ; 11 (1): 821 Nephropedia Template TP
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Antiviral activity of lambda-carrageenan against influenza viruses and severe acute respiratory syndrome coronavirus 2 #MMPMID33436985
Jang Y; Shin H; Lee MK; Kwon OS; Shin JS; Kim YI; Kim CW; Lee HR; Kim M
Sci Rep 2021[Jan]; 11 (1): 821 PMID33436985show ga
Influenza virus and coronavirus, belonging to enveloped RNA viruses, are major causes of human respiratory diseases. The aim of this study was to investigate the broad spectrum antiviral activity of a naturally existing sulfated polysaccharide, lambda-carrageenan (lambda-CGN), purified from marine red algae. Cell culture-based assays revealed that the macromolecule efficiently inhibited both influenza A and B viruses with EC(50) values ranging from 0.3 to 1.4 mug/ml, as well as currently circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with an EC(50) value of 0.9 +/- 1.1 mug/ml. No toxicity to the host cells was observed at concentrations up to 300 mug/ml. Plaque titration and western blot analysis verified that lambda-CGN reduced expression of viral proteins in cell lysates and suppressed progeny virus production in culture supernatants in a dose-dependent manner. This polyanionic compound exerts antiviral activity by targeting viral attachment to cell surface receptors and preventing virus entry. Moreover, its intranasal administration to mice during influenza A viral challenge not only alleviated infection-mediated reductions in body weight but also protected 60% of mice from virus-induced mortality. Thus, lambda-CGN could be a promising antiviral agent for preventing infection with several respiratory viruses.