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10.1126/science.abe6522 http://scihub22266oqcxt.onion/10.1126/science.abe6522 33436525!7932103!33436525     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2021 ; 371 (6530): 741-745 Nephropedia Template TP {{tp|p=33436525|t=2021. Immunological characteristics govern the transition of COVID-19 to endemicity |pdf=|usr=}}{{33436525}} gab.com Text Immunological characteristics govern the transition of COVID-19 to endemicity JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=33436525 #FOAvip We are currently faced with the question of how the severity of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may change in the years ahead. Our analysis of immunological and epidemiological data on endemic human coronaviruses (HCoVs) shows that infection-blocking immunity wanes rapidly but that disease-reducing immunity is long-lived. Our model, incorporating these components of immunity, recapitulates both the current severity of SARS-CoV-2 infection and the benign nature of HCoVs, suggesting that once the endemic phase is reached and primary exposure is in childhood, SARS-CoV-2 may be no more virulent than the common cold. We predict a different outcome for an emergent coronavirus that causes severe disease in children. These results reinforce the importance of behavioral containment during pandemic vaccine rollout, while prompting us to evaluate scenarios for continuing vaccination in the endemic phase. Twit Text FOAVip Immunological characteristics govern the transition of COVID-19 to endemicity ????Science http://www.kidney.de/pget.php?&tw=1&pmid=33436525 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33436525 #FOAvip English Wikipedia <ref>{{Cite pmid|33436525}}</ref> Immunological characteristics govern the transition of COVID-19 to endemicity #MMPMID33436525 Lavine JS; Bjornstad ON; Antia R Science 2021[Feb]; 371 (6530): 741-745 PMID33436525show ga We are currently faced with the question of how the severity of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may change in the years ahead. Our analysis of immunological and epidemiological data on endemic human coronaviruses (HCoVs) shows that infection-blocking immunity wanes rapidly but that disease-reducing immunity is long-lived. Our model, incorporating these components of immunity, recapitulates both the current severity of SARS-CoV-2 infection and the benign nature of HCoVs, suggesting that once the endemic phase is reached and primary exposure is in childhood, SARS-CoV-2 may be no more virulent than the common cold. We predict a different outcome for an emergent coronavirus that causes severe disease in children. These results reinforce the importance of behavioral containment during pandemic vaccine rollout, while prompting us to evaluate scenarios for continuing vaccination in the endemic phase. |*Endemic Diseases/prevention & control[MESH] |Adaptive Immunity[MESH] |Adolescent[MESH] |Adult[MESH] |Age Distribution[MESH] |Antibodies, Viral/blood/immunology[MESH] |COVID-19 Vaccines/immunology[MESH] |COVID-19/*epidemiology/*immunology/prevention & control/transmission[MESH] |Child[MESH] |Child, Preschool[MESH] |Communicable Diseases, Emerging/epidemiology[MESH] |Coronavirus Infections/*epidemiology/immunology/mortality[MESH] |Coronavirus/immunology[MESH] |Epidemics[MESH] |Humans[MESH] |Immunoglobulin G/blood[MESH] |Immunoglobulin M/blood[MESH] |Infant[MESH] |Reinfection[MESH] |SARS-CoV-2/immunology/pathogenicity[MESH] |Seroepidemiologic Studies[MESH] |Severe Acute Respiratory Syndrome/epidemiology[MESH]Immunological characteristics govern the transition of COVID-19 to end(epmc).pdf DeepDyve Pubget Overpricing