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10.1017/ice.2021.2

http://scihub22266oqcxt.onion/10.1017/ice.2021.2
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33436122!7870921!33436122
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suck abstract from ncbi


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pmid33436122      Infect+Control+Hosp+Epidemiol 2021 ; 42 (11): 1340-1344
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  • Detection of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) in outpatients: A multicenter comparison of self-collected saline gargle, oral swab, and combined oral-anterior nasal swab to a provider collected nasopharyngeal swab #MMPMID33436122
  • Kandel CE; Young M; Serbanescu MA; Powis JE; Bulir D; Callahan J; Katz K; McCready J; Racher H; Sheldrake E; Quon D; Vojdani OK; McGeer A; Goneau LW; Vermeiren C
  • Infect Control Hosp Epidemiol 2021[Nov]; 42 (11): 1340-1344 PMID33436122show ga
  • BACKGROUND: Widespread testing for severe acute respiratory coronavirus virus 2 (SARS-CoV-2) is necessary to curb the spread of coronavirus disease 2019 (COVID-19), but testing is undermined when the only option is a nasopharyngeal swab. Self-collected swab techniques can overcome many of the disadvantages of a nasopharyngeal swab, but they require evaluation. METHODS: Three self-collected non-nasopharyngeal swab techniques (saline gargle, oral swab and combined oral-anterior nasal swab) were compared to a nasopharyngeal swab for SARS-CoV-2 detection at multiple COVID-19 assessment centers in Toronto, Canada. The performance characteristics of each test were assessed. RESULTS: The adjusted sensitivity of the saline gargle was 0.90 (95% CI 0.86-0.94), the oral swab was 0.82 (95% CI, 0.72-0.89) and the combined oral-anterior nasal swab was 0.87 (95% CI, 0.77-0.93) compared to a nasopharyngeal swab, which demonstrated a sensitivity of 90% when all positive tests were the reference standard. The median cycle threshold values for the SARS-CoV-2 E-gene for concordant and discordant saline gargle specimens were 17 and 31 (P < .001), for the oral swabs these values were 17 and 28 (P < .001), and for oral-anterior nasal swabs these values were 18 and 31 (P = .007). CONCLUSIONS: Self-collected saline gargle and an oral-anterior nasal swab have a similar sensitivity to a nasopharyngeal swab for the detection of SARS-CoV-2. These alternative collection techniques are cheap and can eliminate barriers to testing, particularly in underserved populations.
  • |*COVID-19[MESH]
  • |*Outpatients[MESH]
  • |Humans[MESH]
  • |Nasopharynx[MESH]
  • |SARS-CoV-2[MESH]
  • |Saliva[MESH]


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