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10.23736/S2724-6507.20.03402-1 http://scihub22266oqcxt.onion/10.23736/S2724-6507.20.03402-1 33435650!ä!33435650 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33435650&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Minerva+Endocrinol+(Torino) 2021 ; 46 (2): 193-201 Nephropedia Template TP {{tp|p=33435650|t=2021. Obesity and COVID-19: the ominous duet affecting the renin-angiotensin system |pdf=|usr=}}{{33435650}} gab.com Text Obesity and COVID-19: the ominous duet affecting the renin-angiotensin system JO: Minerva Endocrinol (Torino) http://www.kidney.de/pget.php?&tw=1&pmid=33435650 #FOAvip The world population is facing a health challenge never seen since the Spanish influenza of one hundred years ago. During the last months, the scientific community has been debating on the potential harmful effect of angiotensin-converting-enzyme inhibitors (ACEi) or angiotensin II receptor type 1 receptor blockers (AT1-receptor blockers, ARBs) during the COVID-19 pandemic. That is because the S spike protein of SARS-CoV viruses utilizes the angiotensin-converting enzyme 2 (ACE2) as a receptor to enter alveolar epithelial cells. Obesity, often associated to type 2 Diabetes, was shown to worsen the prognosis of SARS-CoV-2 infection. Herein we discuss the complex interaction between the renin-angiotensin-aldosterone system (RAAS), its receptors, and the interaction with the Kallikrein-Kinin-system (KKS) and the potential activation of the coagulation cascade. Alteration of the equilibrium between the RAAS system and the KKS cascade may explain the frequent thromboembolic complications of COVID-19 mainly seen in obese and diabetic-obese patients. In contrast, angiotensin (1-7) contributes to maintaining a correct balance between RAAS and KKS system. Our conclusion is that the higher mortality rate in patients with obesity is linked to the alteration of RAS and RAS-KKS interaction consequent to SARS-CoV-2-cell entrance. At present, no data support the necessity of modifying ACEi or ARBs treatment in hypertensive patients. Twit Text FOAVip Obesity and COVID-19: the ominous duet affecting the renin-angiotensin system ????Minerva Endocrinol (Torino) http://www.kidney.de/pget.php?&tw=1&pmid=33435650 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33435650 #FOAvip English Wikipedia <ref>{{Cite pmid|33435650}}</ref> Obesity and COVID-19: the ominous duet affecting the renin-angiotensin system #MMPMID33435650 Luzi L; Bucciarelli L; Ferrulli A; Terruzzi I; Massarini S Minerva Endocrinol (Torino) 2021[Jun]; 46 (2): 193-201 PMID33435650show ga The world population is facing a health challenge never seen since the Spanish influenza of one hundred years ago. During the last months, the scientific community has been debating on the potential harmful effect of angiotensin-converting-enzyme inhibitors (ACEi) or angiotensin II receptor type 1 receptor blockers (AT1-receptor blockers, ARBs) during the COVID-19 pandemic. That is because the S spike protein of SARS-CoV viruses utilizes the angiotensin-converting enzyme 2 (ACE2) as a receptor to enter alveolar epithelial cells. Obesity, often associated to type 2 Diabetes, was shown to worsen the prognosis of SARS-CoV-2 infection. Herein we discuss the complex interaction between the renin-angiotensin-aldosterone system (RAAS), its receptors, and the interaction with the Kallikrein-Kinin-system (KKS) and the potential activation of the coagulation cascade. Alteration of the equilibrium between the RAAS system and the KKS cascade may explain the frequent thromboembolic complications of COVID-19 mainly seen in obese and diabetic-obese patients. In contrast, angiotensin (1-7) contributes to maintaining a correct balance between RAAS and KKS system. Our conclusion is that the higher mortality rate in patients with obesity is linked to the alteration of RAS and RAS-KKS interaction consequent to SARS-CoV-2-cell entrance. At present, no data support the necessity of modifying ACEi or ARBs treatment in hypertensive patients. |*Renin-Angiotensin System[MESH] |COVID-19/*complications/mortality/physiopathology[MESH] |Humans[MESH] |Kallikrein-Kinin System[MESH] |Obesity/*complications/mortality/physiopathology[MESH]Obesity and COVID-19: the ominous duet affecting the renin-angiotensin(epmc).pdf DeepDyve Pubget Overpricing