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10.1084/jem.20202135 http://scihub22266oqcxt.onion/10.1084/jem.20202135 33433624!7808299!33433624     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Exp+Med 2021 ; 218 (3): ä Nephropedia Template TP {{tp|p=33433624|t=2021. Neuroinvasion of SARS-CoV-2 in human and mouse brain |pdf=|usr=}}{{33433624}} gab.com Text Neuroinvasion of SARS-CoV-2 in human and mouse brain JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=33433624 #FOAvip Although COVID-19 is considered to be primarily a respiratory disease, SARS-CoV-2 affects multiple organ systems including the central nervous system (CNS). Yet, there is no consensus on the consequences of CNS infections. Here, we used three independent approaches to probe the capacity of SARS-CoV-2 to infect the brain. First, using human brain organoids, we observed clear evidence of infection with accompanying metabolic changes in infected and neighboring neurons. However, no evidence for type I interferon responses was detected. We demonstrate that neuronal infection can be prevented by blocking ACE2 with antibodies or by administering cerebrospinal fluid from a COVID-19 patient. Second, using mice overexpressing human ACE2, we demonstrate SARS-CoV-2 neuroinvasion in vivo. Finally, in autopsies from patients who died of COVID-19, we detect SARS-CoV-2 in cortical neurons and note pathological features associated with infection with minimal immune cell infiltrates. These results provide evidence for the neuroinvasive capacity of SARS-CoV-2 and an unexpected consequence of direct infection of neurons by SARS-CoV-2. Twit Text FOAVip Neuroinvasion of SARS-CoV-2 in human and mouse brain ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=33433624 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33433624 #FOAvip English Wikipedia <ref>{{Cite pmid|33433624}}</ref> Neuroinvasion of SARS-CoV-2 in human and mouse brain #MMPMID33433624 Song E; Zhang C; Israelow B; Lu-Culligan A; Prado AV; Skriabine S; Lu P; Weizman OE; Liu F; Dai Y; Szigeti-Buck K; Yasumoto Y; Wang G; Castaldi C; Heltke J; Ng E; Wheeler J; Alfajaro MM; Levavasseur E; Fontes B; Ravindra NG; Van Dijk D; Mane S; Gunel M; Ring A; Kazmi SAJ; Zhang K; Wilen CB; Horvath TL; Plu I; Haik S; Thomas JL; Louvi A; Farhadian SF; Huttner A; Seilhean D; Renier N; Bilguvar K; Iwasaki A J Exp Med 2021[Mar]; 218 (3): ä PMID33433624show ga Although COVID-19 is considered to be primarily a respiratory disease, SARS-CoV-2 affects multiple organ systems including the central nervous system (CNS). Yet, there is no consensus on the consequences of CNS infections. Here, we used three independent approaches to probe the capacity of SARS-CoV-2 to infect the brain. First, using human brain organoids, we observed clear evidence of infection with accompanying metabolic changes in infected and neighboring neurons. However, no evidence for type I interferon responses was detected. We demonstrate that neuronal infection can be prevented by blocking ACE2 with antibodies or by administering cerebrospinal fluid from a COVID-19 patient. Second, using mice overexpressing human ACE2, we demonstrate SARS-CoV-2 neuroinvasion in vivo. Finally, in autopsies from patients who died of COVID-19, we detect SARS-CoV-2 in cortical neurons and note pathological features associated with infection with minimal immune cell infiltrates. These results provide evidence for the neuroinvasive capacity of SARS-CoV-2 and an unexpected consequence of direct infection of neurons by SARS-CoV-2. |*Angiotensin-Converting Enzyme 2/antagonists & inhibitors/metabolism[MESH] |*COVID-19/metabolism/pathology[MESH] |*Cerebral Cortex/metabolism/pathology/virology[MESH] |*Neurons/metabolism/pathology/virology[MESH] |Animals[MESH] |Antibodies, Blocking/*chemistry[MESH] |Disease Models, Animal[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Mice[MESH] |Middle Aged[MESH] |Organoids/metabolism/pathology/virology[MESH]Neuroinvasion of SARS-CoV-2 in human and mouse brain (epmc).pdf DeepDyve Pubget Overpricing