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10.1002/jmv.26791 http://scihub22266oqcxt.onion/10.1002/jmv.26791 33433004!8012999!33433004     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Med+Virol 2021 ; 93 (7): 4616-4619 Nephropedia Template TP {{tp|p=33433004|t=2021. Mutations in SARS-CoV-2 nsp7 and nsp8 proteins and their predicted impact on replication/transcription complex structure |pdf=|usr=}}{{33433004}} gab.com Text Mutations in SARS-CoV-2 nsp7 and nsp8 proteins and their predicted impact on replication/transcription complex structure JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=33433004 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (RdRp) has been identified to be a mutation hot spot, with the P323L mutation being commonly observed in viral genomes isolated from North America. RdRp forms a complex with nonstructural proteins nsp7 and nsp8 to form the minimal replication/transcription machinery required for genome replication. As mutations in RdRp may affect formation of the RdRp-nsp7-nsp8 supercomplex, we analyzed viral genomes to identify mutations in nsp7 and nsp8 protein sequences. Based on in silico analysis of predicted structures of the supercomplex comprising of native and mutated proteins, we demonstrate that specific mutations in nsp7 and nsp8 proteins may have a role in stabilization of the replication/transcription complex. Twit Text FOAVip Mutations in SARS-CoV-2 nsp7 and nsp8 proteins and their predicted impact on replication/transcription complex structure ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=33433004 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33433004 #FOAvip English Wikipedia <ref>{{Cite pmid|33433004}}</ref> Mutations in SARS-CoV-2 nsp7 and nsp8 proteins and their predicted impact on replication/transcription complex structure #MMPMID33433004 Reshamwala SMS; Likhite V; Degani MS; Deb SS; Noronha SB J Med Virol 2021[Jul]; 93 (7): 4616-4619 PMID33433004show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (RdRp) has been identified to be a mutation hot spot, with the P323L mutation being commonly observed in viral genomes isolated from North America. RdRp forms a complex with nonstructural proteins nsp7 and nsp8 to form the minimal replication/transcription machinery required for genome replication. As mutations in RdRp may affect formation of the RdRp-nsp7-nsp8 supercomplex, we analyzed viral genomes to identify mutations in nsp7 and nsp8 protein sequences. Based on in silico analysis of predicted structures of the supercomplex comprising of native and mutated proteins, we demonstrate that specific mutations in nsp7 and nsp8 proteins may have a role in stabilization of the replication/transcription complex. |Amino Acid Sequence[MESH] |Computer Simulation[MESH] |Coronavirus RNA-Dependent RNA Polymerase/chemistry/*genetics/metabolism[MESH] |Genome, Viral[MESH] |Humans[MESH] |Models, Molecular[MESH] |Mutation[MESH] |Protein Stability[MESH] |SARS-CoV-2/chemistry/genetics/*physiology[MESH] |Viral Nonstructural Proteins/chemistry/*genetics/metabolism[MESH]Mutations in SARS-CoV-2 nsp7 and nsp8 proteins and their predicted imp(epmc).pdf DeepDyve Pubget Overpricing